عنوان مقاله [English]
The regeneration process is not only affected by interactions between cells but also the surfaces chemistry of biomaterials. For this reason, modifying the surface of electrospun fibers with biomolecules is a suitable method to increase adhesion and cellular organization. There are two general approaches to modify electrospun nanofibers, which are performed in different ways. Loading biological agents in a polymer solution is a common method for trapping biomolecules in the scaffold structure, in which the molecule is located in the fibrous labyrinth and plays its role. However, due to the limitations of this method, post-modification methods have been considered as an alternative path. This type of modification can be achieved by physical adsorption of biomolecules on the fiber surface or by chemical bonding. Due to the capabilities of click chemistry, clickable electrospun structures provide a promising path for linking different biomolecules, that are suitable for different purposes of tissue engineering. In this article, the latest research performed on the functionalization and modification of electrospun structures with different types of click reactions are reviewed. Obviously, achieving smart systems that stimulate and control the cellular activities requires familiarity with the latest research in this field, which is the main goal of this review article.