عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Today biosensors are synthesized in analytical chemistry, which are used for clinical diagnostics, environmental analysis, product monitoring, detection and drug screening.Synthetic biomimetic receptors like molecular imprinting polymer (MIPs) have shown to be a potential alternative to biomolecules as recognition element for biosensing. MIPs are capable of recognizing and binding target molecules with similar specificity and selectivity. One of the main challenges in MIP sensor development is the miniaturization of MIP structures and their interfacing with transducers or with microchips. So, photostructuring is suggested as one of the most suitable methods for patterning MIPs at the micro and nano scale on the transducer surface. In this study, photopolymerization, photopatterning of MIPs and their biosensing applications are described from 1972 up to 2012. Also, some lithoghraphy methods are recommended for MIP photostructures. MIP fifilms patterning by the use of optical methods is fairly compared to other structuring approaches such as soft lithography or mechanical microspotting, which is a new method with ability to synthesize nanostructure with high quality, precision and resolution. The contact and proximity printing, projection photolithography, microstereo-lithography, and near-fifield assisted optical lithography were all successfully combined with MIPs, resulting in specifificity and selectivity high-resolution patterns.
1. He H., Zhou L., Yi W., Li Ch., Yao J., Zhang W., Zhang Q., Li M., Li H., and Dong W., Detection of Trace Microcystin-LR on a 20 MHz QCM Sensor Coated with in Situ Self-Assembled MIPs, Talanta, 131, 8-13, 2015.
2. Wu Z., Tao C., Lin C., Shen D., and Li G., Label-Free Colorimetric Detection of Trace Atrazine in Aqueous Solution by Using Molecularly Imprinted Photonic Polymers, Chem. Eur. J., 14, 11358-11368, 2008.
3. Linares A.V., Vandevelde F., Belmont A.S., Pantigny J., and Haupt K., Polymer Films Composed of Surface-Bound Nanofilaments with a High Aspect Ratio, Molecularly Imprinted with Small Molecules and Proteins, Adv. Mater., 19, 1299-1303, 2009.
4. Jha Sunil K., and Hayashi K., Polyacrylic Acid Polymer and Aldehydes Template Molecule based MIPs Coated QCM Sensors for Detection of Pattern Aldehydes in Body Odor, Sensor Actuat. B: Chem., 206, 471-487, 2015.
5. Cunningham M.F., Controlled/Living Radical Polymerization in Aqueous Dispersed Systems, Prog. Polym. Sci., 33, 365–398, 2008.
6. Odian G., Principles of Polymerization, John Wiley and Sons, New York, 4th ed., Ch. 3, 198-330, 2004.
7. Jha Sunil K. and Hayashi K., A Quick Responding Quartz Crystal Microbalance Sensor Array Based on Molecular Imprinted Polyacrylic Acids Coating for Selective Identification of Aldehydes in Body Odor, Talanta, 134, 105-119, 2015.
8. Deeb C., Ecoffet C., Bachelot R., Plain J., Bouhelier A., and Soppera O., Plasmon-based Free-Radical Photopolymerization: Effect of Diffusion on Nanolithography Processes, J. Am. Chem. Soc., 133, 10535-10542, 2011.
9. EL-Sharif Hazim F., Aizawa H., and Reddy Subrayal M., Spectroscopic and Quartz Crystal Microbalance (QCM) Characterisation of Protein-based MIPs, Sensor Actuat. B-Chem., 206, 239-245, 2015.
10. Uzun L. and Turner Anthony P.F., Molecularly-Imprinted Polymer Sensors: Realising Their Potential, Biosens. Bioelectron., 76, 131-144, 2016.
11. Barrios C.A., Zhenhe C., Navarro-Villoslada F., Lopez-Romero D., and Moreno Bondi M.C., Molecularly Imprinted Polymer Diffraction Grating as Label-free Optical Bio(Mimetic)Sensor, Biosens. Bioelectron., 26, 2801-2804, 2011.
12. Soppera O., Jradi S., and Lougnot D.J., Photopolymerization with Micro Scale Resolution: Influence of the Physico-Chemical and Photonic Parameters, J. Polym. Sci. Polym. Chem., 46, 3783-3794, 2008.
13. De Middeleer G., Dubruel P., and De Saeger S., Characterization of MIP and MIP Functionalized Surfaces: Current State-of-the-Art, Trac-Trend. Anal. Chem., 76, 71-85, 2016.
14. Kyzas G.Z., Bikiaris D.N., and Lazaridis N.K., Selective Separation of Basic and Reactive Dyes by Molecularly Imprinted Polymers (MIPs), Chem. Eng. J., 149, 263-272, 2009.
15. Yang Y., Yi Ch., Luo J., Liu R., Liu J., Jiang J., and Liu X., Glucose Sensors Based on Electrode Position of Molecularly Imprinted Polymeric Micelles: A Novel Strategy for MIP Sensors, Biosens. Bioelectron., 26, 2607-2612, 2011.
16. Molecularly Imprinted Sensors, Piletsky S., Piletsky S., and Chianella I. (Eds.), Elsevier, Ch. 14, 339-354, 2012.
17. Huang H.C., Lin C.I., Joseph A.K., and Lee Y.D., Photo-lithographically Impregnated and Molecularly Imprinted Polymer Thin Film for Biosensor Applications, J. Chromatogr. A, 1027, 263-268, 2004.
18. Lautner G., Kaev J., Reut J., Oepik A., Rappich J., Syritski V., and Gyurcsanyi R.E., Selective Artificial Receptors based on Micropatterned Surface-Imprinted Polymers for Lable Free Detection of Proteins by SPR Imaging, Adv. Funct. Mater., 21, 591-597, 2011.
19. Linares A.V., Falcimaigne Cordin A., Gheber L.A., and Haupt K., Patterning Nanostructured, Synthetic, Polymeric Receptors by Simultaneous Projection Photolithography, Nanomolding, and Molecular Imprinting, Small, 7, 2318-2325, 2011.
20. Reimhult K., Yoshimatsu K., Risveden K., Chen S., Ye L., and Krozer A., Characterization of QCM Sensor Surfaces Coated with Molecularly Imprinted Nanoparticles, Biosens. Bioelectron., 23, 1908-1914, 2008.
21. Ton X.A., Acha V., Bonomi P., Sum Bui B.T., and Haupt K., A Disposable Evanescent Wave Fiber Optic Sensor Coated with a Molecularly Imprinted Polymer as a Selective Fluorescence Probe, Biosens. Bioelectron., 64, 359-366, 2015.