عنوان مقاله [English]
Wound healing is a complex process and is accompanied by persistent inflammation, cell dysfunction, and angiogenesis limitations, leading to long-term medical care, high cost, and poor quality of treatment. The use of antibiotics, dressings, and skin alternatives are current methods of wound healing treatments. However, the existing wound dressings are not yet able to fully restore all of the skin's structural and functional characteristics. Therefore, the development of asymmetric membranes that mimic the structure and function of human skin is desired as more efficient structures in the healing process as well as skin tissue engineering. Wet or dry/wet phase inversion, supercritical carbon dioxide (scCO2) phase inversion, and electrospinning of polymer solutions are the common methods for the fabrication of multilayer structures. Among these, the electrospinning technique, due to its ease and versatility, the possibility of using different polymers, and the possibility of tailoring dressings in terms of specific structures of skin layers is promising. Moreover, another generation of emerging therapies is based on the loading of potential cells for wound healing acceleration. In this review article, in the first part, the last achievements obtained on asymmetric structures from the viewpoint of used polymers are reviewed. Then, the electrospun structures containing special cells are discussed.