مروری بر فن‌ها و زیست‌جوهرهای زیست‌چاپگرهای سه‌بعدی

نوع مقاله : تالیفی

نویسندگان

1 دانشجو/ دانشگاه اصفهان

2 دانشگاه اصفهان، دانشکده شیمی، گروه شیمی پلیمر

3 هیات علمی/ دانشگاه اصفهان

چکیده

با پیشرفت شگفت ­انگیز دانش پزشکی، تولید یا جایگزینی بافت یا اندام روش طلایی در درمان برخی بیماری ­ها و ضایعات است. فناوری زیست­ چاپ، تحولی در این زمینه ایجاد کرده است. در راستای تکامل این فناوری، توسعه­ چاپگرهای پیشرفته و زیست­ مواد نوین، عامل اثرگذاری بر دستیابی به پیشرفت­ های اخیر است که بخشی از آن مرهون تکرارپذیری و بازساخت داربست با معماری مدنظر است. در این مقاله، تعریف ­های اساسی فناوری زیست­ چاپ سه­ بعدی ارائه شده و عناصر دخیل در موفقیت این فرایند از نقطه ­­نظر دستگاه­ وری و زیست­ مواد استفاده ­شده بررسی می ­شود. در این راستا، ابتدا زیست­ چاپگرهای توسعه ­یافته و سپس، اهمیت هندسه افشانک و ویژگی­ های اساسی زیست ­مواد ایده ­آل، به ­ویژه هیدروژل­ ها، مرور شده است. ویژگی­ های معماری، مکانیکی و زیستی یک داربست، ضروری ­ترین ویژگی یک سازه­ چاپ ­شده بوده و متأثر از ساختار داخلی و جوهر استفاده ­شده است. با توجه به اهمیت زیاد جوهر در فرایند چاپ، روش­های تهیه هیدروژل از دید تشکیل شبکه و اهمیت آن­ها در زمینه طراحی زیست­ مواد کاراتر بررسی شده است. بدیهی است، با آشنایی با عوامل دستگاهی مناسب و پلیمرهایی با خواص ویژه می ­توان چشم ­انداز جالبی را در طراحی داربست­ های زیستی داشت.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

A Review on 3D Bioprinting Techniques and Bioinks

نویسندگان [English]

  • Negar Farzanehfar 1
  • mehdi sheikhi 2
  • Fatemeh Rafiemanzelat 3
1 Student/ Isfahan University
2
3 Faculty/ University of Isfahan
چکیده [English]

With the exciting advancement in medical knowledge, the production or replacement of tissue or organs has the gold standard in the treatment of some diseases and lesions. Bioprinting technology is a breakthrough in this field. In line with the evolution of this technology, the development of advanced printers and new biomaterials are the factors affecting achievement of recent advances, which is partially due to the reproducibility and scaffold regeneration with the intended architecture. In this paper, the basic definitions of the three- dimensional (3D) bioprinting technology and the main elements associated with this technology are reviewed. This review aims are to focus on different technologies developed for the printing of biological species. A brief description of complicated nozzle geometry is followed by introducing common bioinks and the requirements for ideal biomaterials, especially hydrogels as novel candidates and their preparation aspects. Architectural, mechanical and biological properties of a scaffold are the most essential characteristics of a printed structure which are affected by the internal structure and the hydrogel precursor. Since innovation in biomaterials is key to the success of bioprinting, hydrogel preparation methods are fully discussed in terms of network formation. By incorporating proper instrumental parameters and tailoring hydrogel precursors, many benefits can be imparted to the final scaffold, providing design elements for next-generation bioinks.

کلیدواژه‌ها [English]

  • 3D printing
  • bioinks
  • bioprinting
  • hydrogel
  • tissue engineering
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