دارو‌رسانی شخصی‌سازی‌شده با کاربرد فناوری نوین چاپ سه‌بعدی

نوع مقاله : تالیفی

نویسنده

گروه شیمی، دانشکده فیزیک و شیمی، دانشگاه الزهرا، ده ونک، تهران، ایران

چکیده

از اهداف مهم صنعت داروسازی، افزایش اثربخشی درمانی داروها در بیماران و کاهش عوارض جانبی آن است. در راستای دست­یابی به این اهداف، باید تجویز دارو برای هر بیمار به ­طور اختصاصی و متناسب با اطلاعات ژنتیکی آن فرد انجام گیرد. زیرا، در هر فرد مقدار جذب دارو، مدت زمان رسیدن دارو به بافت هدف و اثرگذاری دارو بر بیمار متفاوت است. این موضوع به­ خوبی اهمیت پزشکی شخصی­ سازی­ شده را نشان می‌دهد. دارودرمانی در پزشکی شخصی راحتی و سازگاری بیمار را به دنبال دارد. تهیه داروهای شخصی‌سازی شده با فناوری چاپ سه‌بعدی امکان‌پذیر بوده که در سال‌های اخیر توجه زیادی به آن معطوف شده است. با استفاده از این فناوری، امکان طراحی و ساخت داروهایی با اشکال مختلف در بستر پلیمری برای پذیرش کودکان و امکان طراحی و بارگذاری چند دارو در یک دُز دارویی با هدف راحتی سالمندان وجود دارد. همچنین با استفاده از این فناوری، الگوی رهایش دارو را می‌توان با تغییر در ضخامت یا نوع لایه پلیمری تنظیم کرد. نیم­رخ رهایش دارو را می‌توان به‌گونه‌ای طراحی کرد که هر دارو سینتیک رهایش ویژه خود را داشته باشد. در این مقاله، پس از توضیح اهمیت دارورسانی شخصی‌سازی ­شده، به تعدادی از داروهای کپسول­دارشده در حامل‌های پلیمری پرداخته می‌شود. سپس، برخی از انواع سامانه­ های دارورسانی نوین مانند زخم‌پوش‌ها و میکروسرنگ‌های تولید شده با این فناوری در سال‌های اخیر، بررسی می­ شوند.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Personalized Drug Delivery with the Use of Modern 3D Printing Technology

نویسنده [English]

  • maryam kashi
چکیده [English]

One of the important goals of the pharmaceutical indusry is to increase the therapeutic efectiveness of drugs for  patients and reduce their side efects. In order to fulfll these targets, the drugs should be prescribed to each patient individually and in accordance with the patient's genetic information, because in each patient, the amount of drug absorption, the time that drug reaches the target tissue and the efect of drug on the patient's organ are diferent. This clearly shows the importance of personalized medicine. Medication in personalized medicine leads to patient comfort and adaptation. The production of personalized drugs with 3D printing technology has been possible, which has  received a lot of attention in recent years. Using this technology, it is possible to design and made drugs with diferent shapes and color for children and load some drugs in one dosage (polypill) for elderly people. Also, using this  technology, the drug release pattern can be adjused by changing the thickness or type of polymer layer. The drug  release profle can be designed in such a way that each drug in polypill has special release pattern. In this article, after explaining the importance of personalized drug delivery, some encapsulated drugs in polymeric carriers are discussed. Then, some new drug delivery sysems, such as wound dressings and microsyringes produced with this technology in recent years, are briefy reviewed.

کلیدواژه‌ها [English]

  • personalized medicine
  • wound dressing
  • microsyringe
  • drug release kinetics
  • fused deposition molding
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