کاربرد نانوالیاف الکتروریسی‌شده در مهندسی بافت: داربست‌هایی با رهایش آهسته عامل های رشد

نوع مقاله : تالیفی

نویسندگان

1 تربیت مدرس

2 دانشگاه تربیت مدرس

چکیده

ﻣﻬﻨﺪﺳﯽ ﺑﺎﻓﺖ، ﯾﮏ روﯾﮑﺮد ﻧﻮﯾﻦ درﻣﺎﻧﯽ اﺳﺖ ﮐﻪ در آن ﺳﻪ ﻋﺎﻣﻞ ﺳﻠﻮل، ﻣﺤﺮک­ﻫﺎی ﻣﻮﻟﮑﻮﻟﯽ و دارﺑﺴﺖ ﻧﻘﺶ مهمی دارﻧﺪ. اﻣﺮوزه ﭘﮋوﻫﺸﮕﺮان ﻣﻬﻨﺪﺳﯽ ﺑﺎﻓﺖ، ﺑﺮای درﻣﺎن ﺑﯿﻤﺎری­ﻫﺎی ﻣﺨﺘﻠﻒ و ﺑﺎزﺗﻮﻟﯿﺪ و جای­گذاری انواع ﺑﺎﻓﺖ­ﻫﺎی ﺑﺪن، از دارﺑﺴﺖ­ﻫﺎی ﻧﺎﻧﻮﻟﯿﻔﯽ به­ منظور ﺗﻘﻠﯿﺪ از ساختار ﺑﺎﻓﺖ ﻃﺒﯿﻌﯽ و به­ عنوان راه­ حلی برای پیشرفت و توسعه داربست­ های مهندسی بافت، اﺳﺘﻔﺎده ﻣﯽ­ﮐﻨﻨﺪ. ﺑدﯾﻦ ﻣﻨﻈﻮر، از میان تمام روش ­های موجود، معمولا اﻟﮑﺘﺮورﯾﺴﯽ انتخاب می­ شود که روش آﺳﺎن و ﻣﻘﺮون ﺑﻪ­ﺻﺮﻓﻪ­ای ﺑﺮای ﺗﻮﻟﯿﺪ اﯾﻦ ﺳﺎزه­ﻫﺎﺳﺖ. زیرا، تنوع و سازه­ های دستگاهی این فرایند، ﺗﻮﻟﯿﺪ ﻣﯿﮑﺮو-ﻧﺎﻧﻮاﻟﯿﺎف را ﺑﺎ ﮔﺴﺘﺮه­ وﺳﯿﻌﯽ از ﺗﺮﮐﯿﺐ و ﺷﮑﻞ امکان­پذیر می­ سازد. افزون بر این، ﺑﺎ اﺳﺘﻔﺎده از اﻧﻮاع ﻣﻮﻟﮑﻮل­ﻫﺎی ­زﯾﺴﺘﯽ و عامل­ های رﺷﺪ ﺑﻪﻫﻤﺮاه اﯾﻦ اﻟﯿﺎف، ﻣﯽ­ﺗﻮان ﭘﺎﺳﺦ ﺳﻠﻮﻟﯽ و ﺑﺎزدﻫﯽ درﻣﺎﻧﯽ را در فرایندﻫﺎی ﻣﻬﻨﺪﺳﯽ ﺑﺎﻓﺖ ارﺗﻘﺎ داد. همچنین، با انتخاب روش مناسب برای بارگذاری این مولکول­ ها، فرایند را در بافت مدنظر به ­خوبی کنترل و هدایت کرد. اﮔﺮﭼﻪ اﻧﺘﻘﺎل و رﻫﺎﯾﺶ ﮐﻨﺘﺮل­ﺷﺪه­ عامل­ های رشد ﻫﻨﻮز با ﭼﺎﻟﺶ­ﻫﺎی بسیاری مواجه است، اﻣﺎ اﻟﯿﺎف اﻟﮑﺘﺮورﯾﺴﯽ ­ﺷﺪه ﻣﯽ­ﺗﻮاﻧﻨﺪ روزﻧﻪ­ ﭘﯿﺸﺮﻓتی برای اﻧﺘﻘﺎل ﻫﺪﻓﻤﻨﺪ و ﮐﻨﺘﺮل­شده داروﻫﺎ و عامل ­های رﺷﺪ در ﻣﻬﻨﺪﺳﯽ ﺑﺎﻓﺖ ﺑﺎﺷﻨﺪ که ﺑﻪ ﻋﻨﻮان دارﺑﺴﺖ­ﻫﺎی رﻫﺎﯾﺶ در ﻋﻠﻮم ﭘﺰﺷﮑﯽ و ﻣﻬﻨﺪﺳﯽ، اﺳﺘﻔﺎده شوند.

کلیدواژه‌ها


عنوان مقاله [English]

Application of Electrospun Nanofibers in Tissue Engineering: Scaffolds with Sustained Release of Growth Factors

نویسندگان [English]

  • Fariba Ganji 1
  • Mahya Baradaran 1
  • ameneh seddighian 2
1 Tarbiat Modares University
2 Tarbiat Modares University
چکیده [English]

Tissue engineering is a novel approach in treatment, in which, three important factors of cell, molecule signals, and scaffolds play a vital role. Nowadays, tissue engineering scientists use nanofibrous scaffolds to treat different diseases, regenerate and replace different body tissues, so as to simulate native tissues, as well as making progress and development in nano fibrous scaffolds engineering studies. To conduct the aforementioned studies, electrospinning is preferred out of various routs, due to its simplicity and cost-effectiveness in fabrication of structures that make the production of micro/nanofibers with a wide range of compositions and forms feasible. Moreover, using various types of biomolecules, biodrugs, and growth factors that are incorporated with in these fibers, would make it possible to improve cell response and treatment yield in tissue engineering processes, along with a suitable control and conduction of the process by selecting a suitable method of molecule loading. Although, there are many challenges regarding loading and controlled delivery of biomolecules through electrospun micro/nanofibers, but they have the potential ability to enhance the drug and growth factor delivery for tissue engineering and drug therapy. In addition, these micro/nanofibers can also be utilized as releasing scaffolds in engineering and medical science.

کلیدواژه‌ها [English]

  • electrospinning
  • tissue engineering
  • controlled delivery
  • scaffold
  • Growth Factor
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