مروری بر هیدروژل‌های کلیک زیست‌پایه تهیه شده با واکنش‌های دیلز‌‌-‌آلدر

نوع مقاله : تالیفی

نویسندگان

1 دانشگاه اصفهان

2 اصفهان، دانشگاه اصفهان، دانشکده شیمی

چکیده

هیدروژل‌ها به ­دلیل قابلیت زیاد جذب و نگه­داشت آب، کاربرد‌های گسترده‌ای را در زمینه‌های پزشکی، صنعتی و محیط ‌زیست نظیر مهندسی بافت، دارورسانی و جذب آلاینده‌های زیستی یافته ­اند. افزون بر مواد سنتزی، هیدروژل‌ها را می‌توان از مواد اولیه زیست­ پایه غیرسمی، زیست‌سازگار و زیست‌تخریب­ پذیر تهیه کرد. اخیراً از واکنش کلیک دیلز-آلدر به­ منظور تهیه هیدروژل‌های کلیک زیست ­پایه با خواص بهبودیافته بهره گرفته شده‌ است. در پی واکنش دیلز-آلدر یک حلقه شش‌تایی از طریق واکنش [4+2]  بین یک دی‌ان غنی از الکترون و دی‌ان­ دوست با کمبود الکترون تشکیل می‌شود. برای انجام این واکنش، نه تنها نیازی به کاتالیزگر نیست، بلکه هیچ­گونه محصول جانبی نیز ایجاد نمی‌­شود. از ویژگی‌های مهم دیگر واکنش‌های دیلز-آلدر می‌توان به عدم حساسیت به انواع گروه‌های عاملی و برگشت‌پذیری گرمایی از طریق واکنش معکوس دیلز‌-‌آلدر اشاره کرد. از این رو، با استفاده از واکنش دیلز-آلدر، امکان ساخت هیدروژل‌های زیست­ پایه، زیست‌سازگار، پاسخگو به محرک، خود‌ترمیم و درجا تشکیل ­شونده در راستای کاربردهای گوناگون فراهم آمده است. در این مقاله، پس از مرور کوتاهی بر هیدروژل‌ها و واکنش­ های کلیک، مطالعات اخیر و اهداف آن­ها در زمینه تهیه انواع هیدروژل‌های زیست­ پایه با استفاده از واکنش­ های دیلز-آلدر تشریح شده است.

کلیدواژه‌ها


عنوان مقاله [English]

A Review on Bio-Based Click Hydrogels Prepared by Diels-Alder Reactions

نویسندگان [English]

  • Abbas Mohammadi 1
  • Alireza Fatahi 2
1 University of Isfahan
2 Department of Chemistry,University of Isfahan,
چکیده [English]

D ue to their hydrophilic network and their high ability to absorb and retain large amounts of water, hydrogels are widely used in medicine, industry, and the environment for different applications such as tissue engineering, drug delivery, and adsorption of pollutants. In addition to synthetic materials, hydrogels can be made from non-toxic, highly biocompatible, and biocompatible bio-based compounds. Recently, Diels-Alder cycloaddition reaction has been used to produce hydrogels with improved properties. Following Diels-Alder reaction, a six-membered ring is formed by the [4+2] cycloaddition between an electron-rich diene and an electron-deficient dienophile. To perform this reaction, no catalyst is required, and moreover no by-products are produced. Other important features of Diels-Alder reactions include insensitivity to various functional groups and thermal reversibility through retro-Diels-Alder reaction. However, by using the Diels-Alder reaction, it is possible to produce biocompatible bio-based hydrogels with an enhanced performance like stimulus-responsivity, self-healing property, and in-situ forming ability for a variety of applications. In this article, after a brief review of hydrogels and click reactions, recent studies and their objectives for the preparation of various biobased hydrogels using Dils-Alder reactions are discussed.

کلیدواژه‌ها [English]

  • Hydrogel
  • bio-based polymers
  • physical crosslinking
  • chemical crosslinking
  • Diels-Alder reaction
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