مروری بر کاربرد داربست‌های اصلاح‌شده با درخت‌سان‌ها در مهندسی بافت

نوع مقاله : تالیفی

نویسندگان

1 دانشگاه امیر کبیر-دانشکده مهندسی مواد و متالورژی

2 دانشگاه امیرکبیر

10.22063/basparesh.2025.35591.1719

چکیده

مهندسی بافت، علمی چندجانبه است که در آن از اصول مهندسی، پزشکی و فیزیولوژی به ترمیم بافت آسیب‌دیده یا بازسازی بافت ازدست‌رفته به‌کمک رشد و تکثیر سلول‌ها استفاده می‌شود. این کار در بستری به نام داربست انجام می‌شود. داربست‌ها به‌عنوان زیست‌کامپوزیت برای اهداف مختلف از‌جمله دارورسانی، مهندسی بافت، ترمیم زخم و پوست استفاده می‌شوند. این ترکیبات، ساختار متخلخلی دارند که بستر مناسبی را برای تکثیر و رشد سلول‌ها فراهم می‌کنند. در طراحی داربست‌ها به‌عنوان بستر رشد سلول‌‌ها، لازم است به عوامل مهمی ازجمله تعداد و اندازه تخلخل‌ها، آب‌دوستی، زیست‌سازگازی، خواص مکانیکی مطلوب و قابلیت برخورداری از ساختارهای سه‌بعدی و پیچیده توجه شود تا هدف مهندسی بافت برآورده شود. اصلاح ساختار داربست‌ها به‌منظور افزایش کارایی و عملکرد آن‌ها و رفع نواقص و ضعف این ساختارها در مهندسی بافت انجام می‌شود. از میان تمام درخت‌سان‌ها، پلی(آمیدوآمین) (PAMAM) به‌دلیل زیست‌سازگاری، کنترل‌پذیری اندازه و ایمنی‌زایی کم برای اصلاح سطحی داربست‌ها استفاده می‌شود. ازجمله اصلاحاتی که روی داربست‌ها انجام شده، اصلاح داربست پلی‌کاپرولاکتون (PCL) با PAMAM نسل دو، برای انتقال داروی ضدسرطان کورکومین است تا فعالیت ضدسرطان آن بررسی شود. نتایج نشان داد با افزایش غلظت PAMAM، میزان مهار سلول‌های سرطان سینه از %5/31 به %4/42 افزایش یافت. در این مقاله، مهندسی بافت، کاربرد داربست‌های اصلاح‌شده با درخت‌سان‌های مختلف و بهبود خواص داربست‌ها در مهندسی بافت معرفی می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A Review on the Application of Scaffolds Modified with Dendrimer- in Tissue Engineering

نویسندگان [English]

  • Sepideh Amjad-Iranagh 1
  • Maryam Bendokht 2
1 Department of Materials and Metallurgical Engineering
2 Department of Materials and Metallurgical engineering
چکیده [English]

Tissue engineering is a multidisciplinary science that combines engineering, medicine, and physiology to repair damaged tissues or regenerate lost tissues through the growth and proliferation of cells. This process is carried out within a structure known as a scaffold. Scaffolds as bio-composites are used in various areas such as drug delivery, tissue engineering, wound healing and skin regeneration. These structures are porous, providing a suitable environment for cell proliferation and growth. In designing scaffolds as a platform for cell growth, it is necessary to consider key factors such as pore size and distribution, hydrophilicity, biocompatibility, desirable mechanical properties, and the ability to mimic complex three-dimensional structures to support the aims of tissue engineering. Scaffold modification is performed to enhance their efficiency and performance, as well as to overcome existing limitations and challenges. Among dendrimers, poly(amidoamine) (PAMAM) has been widely used for surface modification of scaffolds, due to its biocompatibility, controllable size, and low immunogenicity. One example is the incorporation of second-generation PAMAM into polycaprolactone (PCL) scaffolds for the delivery of the anticancer drug curcumin to evaluate its anticancer activity. The results showed that with increasing PAMAM concentration, the inhibition rate of breast cancer cells increased from 31.5% to 42.4%. In this article, tissue engineering, the application of dendrimer-modified scaffolds, and the improvement of scaffold properties in tissue engineering are introduced.

کلیدواژه‌ها [English]

  • dendrimer
  • scaffold
  • tissue engineering
  • drug delivery
  • surface modification

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