مروری بر داربست های زیست تخریب پذیر هیبریدی در مهندسی بافت و زخم پوش ها

نوع مقاله : گزارش

نویسندگان

1 گروه صنایع چوب و کاغذ - دانشگاه فنی و حرفه ای، تهران، ایران

2 جراح و متخصص زنان و زایمان، دانشگاه علوم پزشکی اصفهان

3 دانشگاه تهران

چکیده

پلیمرهای زیست تخریب پذیر کاربردهای متعددی در زمینه زیست پزشکی، به ویژه در زمینه مهندسی بافت و سامانه های دارورسانی دارند. از مهم ترین ویژگی های آن ها غیرسمی بودن، تجزیه پذیری، قابلیت حمل دارو و کاربرد گسترده در تولید زخم پوش هاست. در این مقاله، اثر برخی از داربست های زیست تخریب پذیر تشکیل شده با خاصیت ضدباکتری، زیست تخریب پذیری، زیست سازگاری، قابلیت
دارورسانی و ضدآب بر التیام زخم و ترمیم بافت مرور شده است. داربست های زیست تخریب پذیر قابلیت هایی در راستای ترمیم بافت و جلوگیری از انتشار باکتری در محل زخم دارند. در مطالعه حاضر، انواع داربست ها با نانوالیاف زیست تخریب پذیر مقایسه و کاربردهای آن ها را در ارتباط با انواع داروها و مواد ترمیم کننده بررسی شده است. کیتوسان، آلژینات، نانوسلولوز، پلی کاپرولاکتون (PCL)، پلی لاکتیک اسید (PLA)، ژلاتین، پلی وینیل الکل (PVA)، کلاژن، پلی هیدروکسی آلکانوات ازجمله کاربردی ترین پلیمرها برای تولید داربست های زیست تخریب پذیر هستند. مقایسه نشان داد، کیتوسان به عنوان بستر بسیار مناسب برای دارورسانی عملکرد ضدباکتری اثرگذاری در ساخت زخم پوش های ضدآب دارد. گفتنی است، PVA ،PCL ،PLA از مهم ترین پلیمرهای زیست تخریب پذیر استفاده شده در داربست های التیام زخم هستند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Hybrid Biodegradable Scaffolds in Tissue Engineering and Wound Dressings- A Review

نویسندگان [English]

  • Amir Mohamadpour tesih 1
  • samira shiari 2
  • Mahsa Moazazi 3
1 Department of wood and paper Technical and Vocational University (TVU), Tehran, Iran
2 2. Surgeon and Obstetrician, Isfahan University of Medical Sciences
3 tehran university
چکیده [English]

Biodegradable polymers have many applications in the field of biomedicine, especially in the field of tissue engineering and drug delivery systems. One of their most important features is non-toxicity, degradability, ability to carry and deliver drug, and widespread use in the production of wound dressings. In this article, the effect of some biodegradable scaffolds formed with antibacterial, biodegradability, biocompatibility, drug delivery, and waterproof properties on wound healing and tissue repair has been reviewed. Biodegradable scaffolds have the ability to restore tissue and prevent the spread of bacteria at the wound site. In the present study, various types of scaffolds with biodegradable nanofibers have been
compared and their applications have been investigated in connection with various drugs and restorative materials. Chitosan, alginate, nanocellulose, polycaprolactone (PCL), polylactic acid (PLA), gelatin, polyvinyl alcohol (PVA), collagen, polyhydroxyalkanoate are among the most useful polymers for producing biodegradable scaffolds. The comparison showed that chitosan, as a very suitable substrate for drug delivery, has an effective antibacterial function in making waterproof wound dressings. It should be mentioned that PVA, PCL, PLA are the most important biodegradable polymers used in wound healing scaffolds.

کلیدواژه‌ها [English]

  • Biodegradable polymers
  • wound dressing
  • drug delivery
  • tissue repair
  • antibacteri

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