نوع مقاله : تالیفی
نویسندگان
1 دانشکده شیمی دانشگاه تحصیلات تکمیلی علوم پایه زنجان
2 هیات علمی/دانشگاه تحصیلات تکمیلی علوم پایه زنجان
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Hydrogels are insoluble and three-dimensional polymer networks that have high water absorption and are used as an extracellular matrix for biomedical applications due to their appropriate elasticity and network structure. Self-healing is a property that enables matter to spontaneously and automatically heal damages and restore itself to its normal state. This feature increases the useful life of materials and preserves their main functional properties. Different types of natural, synthetic or synthetic, and semi-synthetic polymers can be used to prepare self-healing hydrogels. Gelatin is a natural polymer with a protein structure, hydrophilic, biocompatible and biodegradable, and consists of a sequence of eighteen types of amino acids such as glycine, proline, hydroxyproline, alanine, etc., which are connected by peptide bonds. Gelatin is obtained from the hydrolysis of collagen that makes up most of the proteins in skin, bone, and cartilage. Due to its biocompatibility, biodegradability, lack of immune response, the ability to modify and prepare numerous derivatives, and its commercial availability, gelatin has been able to be very efficient in preparing a variety of self-healing hydrogels with various applications. Therefore, in this review article, the preparation and application of different types of gelatin-based self-healing hydrogels in various biological fields such as the preparation of tissue engineering scaffolds, drug delivery, motion sensors, wound dressings in the repair of infectious and diabetic wounds, 3D printing for the preparation of scaffolds, sustained protein release, adhesives used in laparoscopic surgeries have been reviewed.
کلیدواژهها [English]
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