مروری بر کاربرد کیتوسان در مهندسی بافت

نوع مقاله : سایر

نویسندگان

1 بخش شیمی، دانشکده علوم، دانشگاه شهید بهشتی

2 بخش شیمی، دانشگاه کاشان

3 بخش شیمی، دانشکده علوم، دانشگاه شیراز

چکیده

در سال های اخیر، پیشرفت های فزاینده و پرشتابی در استفاده از مواد زیست فعال در کاربردهای مهندسی بافت رخ داده است. از این رو، تقاضای روزافزون برای تهیه موادی با خواص فیزیکی، زیستی و مکانیکی مناسب و نیز رفتار تخریب قابل پیش بینی به وجود آمده است. مواد برپایه کیتوسان که از کیتین مشتق می شوند، زیست پلیمرهای منحصربه فردی هستند. این مواد خواص برجسته ای مانند
ضدباکتری بودن، شکل پذیری در ساختارهای مختلف و قابلیت ساخت با طیف گسترده ای از مواد زیست فعال را نشان می دهند. بدین دلیل، مواد برپایه کیتوسان پلی ساکارید غیرسمی بوده و افزون بر زیست سازگاری و زیست تخریب پذیری، زیست فعال ایده آلی نیز هستند. خواص کیتوسان، مانند حلالیت ضعیف در آب یا حلال های آلی، می تواند موجب محدودیت استفاده از آن برای کاربردهای خاص شود. اصلاح شیمیایی زنجیر عموماً با پیوند دادن گروه های عاملی بدون تغییر پیکره اولیه به منظور حفظ خواص اصلی، راهی عالی برای بهبود خواص یا ایجاد خواص جدید در کیتوسان است. کیتوسان پلیمری طبیعی از منابع تجدیدپذیر است که از سخت پوستانی مانند میگو و صنایع غذایی دریایی به دست می آید. فراوانی طبیعی و مقرون به صرفه بودن کیتوسان توجه بسیاری از پژوهشگران را به دلیل استفاده از آن به عنوان جایگزینی برای ساخت داربست در مهندسی بافت جلب کرده است. هدف از این بررسی، ارائه نمایی کلی از کیتوسان و مشتق های آن بوده که در مهندسی بافت استفاده می شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A Review of the Application of Chitosan in Tissue Engineering

نویسندگان [English]

  • Milad Ghezelsofloo 1
  • Abdulhamid Dehghani 2
  • mehdi Sadat-Shojai 3
  • Soheila Ghasemi 3
1 Department of Chemistry, College of Science, Shahid Beheshti University, Tehran, Iran
2 Department of Chemistry, Kashan University
3 Department of Chemistry, College of Science, Shiraz University
چکیده [English]

In recent years, there have been rapid advances in the use of bioactive materials in tissue engineering applications. Therefore, there is an increasing demand for materials with suitable physical, biological and mechanical properties as well as predictable degradation behavior. These materials show outstanding properties such as being antibacterial, malleable in different structures and can be made with a wide range of bioactive materials. For this reason, materials based on chitosan polysaccharide are non-toxic and in addition to biocompatibility and biodegradability, they are also ideal bioactive material. The properties of chitosan, such as poor solubility in water or organic solvents, can limit its use for a
specific application. An excellent way to improve or create new properties of chitosan is chemical chain modification generally by linking functional groups, without changing the primary skeleton in order to preserve the original properties. Chitosan is a natural polymer from renewable resources that is obtained from crustaceans such as shrimp. The natural abundance and cost-effectiveness of chitosan has attracted the attention of many researchers due to its use as an alternative for making scaffolds in tissue engineering. The purpose of this article is to provide an overview of chitosan and chitosan derivatives that are used in tissue engineering.

کلیدواژه‌ها [English]

  • Chitosan
  • Chitosan derivatives
  • Scaffold
  • Tissue Engineering
  • Biocompatible

مراجع

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