نوع مقاله : تالیفی
نویسندگان
1 عضو هیئت علمی / پژوهشگاه پلیمر و پتروشیمی ایران
2 پژوهشگاه پلیمر و پتروشیمی ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
The solubility and permeability of drugs are the most important biopharmaceutical properties that affect their bioavailability. In the biopharmaceutics classification system (BCS), there are a large number of active pharmaceutical ingredients (APIs) with low solubility (BCS classes II and IV) that are rarely offered to the market. Therefore, it is necessary to provide a solution to increase thier solubility. There are many preparation methods to enhance the solubility and dissolution rate of drugs and thereby absorption in the gastrointestinal tract. Among them, the solid dispersion method is considered one of the most important methods. Since 1960s, the development of pharmaceutical formulations based on the solid dispersion method has undergone significant progress. Solvent-based and melting methods can be mentioned for the preparation of drug-containing systems. The use of different substrates from a single polymeric carrier to multiple carriers containing emulsifier in the design of solid dispersion formulations has led to the improvement of the stability and performance of these systems. In this article, the solid dispersion technique for the preparation of pharmaceutical formulations is introduced, and also a summary of the preparation methods and the recent advances in this field are briefly reviewed.
کلیدواژهها [English]
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