مروری بر کاربرد فناوری چاپ سه‌بعدی در سامانه‌های نوین دارورسانی

نوع مقاله : تالیفی

نویسندگان

1 گروه سامانه های دارورسانی، پژوهشگاه پلیمر و پتروشیمی ایران، صندوق پستی 115-14965

2 بخش مهندسی پزشکی، گروه مهندسی علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران

3 پژوهشگاه پلیمر و پتروشیمی ایران

چکیده

در فرایند چاپ سه‌بعدی، اجسام به‌کمک مدل دیجیتالی با قرارگیری لایه‌به‌لایه مواد روی هم ساخته می‌شوند. در سال‌های اخیر، کاربرد روش چاپ سه‌بعدی در ساخت فراورده‌های دارویی با قابلیت رهایش کنترل‌شده دارو مورد توجه قرار گرفته است. از مزایای این روش می‌توان به قابلیت ساخت اشکال دارویی سفارشی برای هر بیمار با شکل هندسی پیچیده همراه با بارگذاری هم‌زمان چند دارو و مواد افزودنی مختلف اشاره کرد. این فن برای ساخت فراورده‌های حاوی داروهای کم‌محلول، پپتیدها،‌ داروهای قوی و دست‌یابی به الگوی رهایش چنددارویی استفاده می‌شود. اشکال دارویی چاپ‌شده با این روش بر اساس نیاز هر بیمار با در‌نظر گرفتن سن، نژاد، وزن و جنسیت دارای اثربخشی بیشتر و سمیت و عوارض جانبی کمتر هستند. چاپگرهای سه‌بعدی از لحاظ روش کار و نوع مواد اولیه، انواع مختلفی دارند. در عرصه پزشکی سه نوع چاپگر شامل چاپگرهای رسوبی نازلی، جوهرافشان و لیتوگرافی سه‌بعدی رایج‌تر هستند. ضروری است، برای به‌دست آوردن نیم‌رخ رهایش مطلوب دارو، پارامترهایی مانند پایداری دارو و ظرفیت بارگذاری آن در هر روش چاپ درنظر گرفته شوند. در این مقاله، فن چاپ سه‌بعدی و سخت‌افزارهای آن معرفی و پژوهش‌های انجام‌شده در سال‌های اخیر در زمینه رهایش کنترل‌شده دارو نیز مرور می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Application of 3D Printing Technology in Novel Drug Delivery Systems: A Review

نویسندگان [English]

  • Arezou Mashak 1
  • Azadeh Ghaee 2
  • Hamid Mobedi 3
1 Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran
2 2Department of life science engineering, Faculty of new sciences and technologies, University of Tehran, Tehran, Iran
3 Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran
چکیده [English]

In 3D printing process, objects are made using a digital model data by adding a material, as layer by layer, to produce a desired geometry. In recent years, the application of 3D printing technology has been considered for the manufacture of pharmaceutical products with the ability of controlled drug delivery. The advantages of this approach include the ability to prepare personalized dosage forms for each patient with complex geometrical shapes along with simultaneous loading of several different drugs and excipients. Manufacturing of products containing low-solubility drugs, potent drugs and peptides as well as achieving the release of multi-drugs profiles are possible through 3D printing technique. The prepared dosage forms by 3D printing method based on patient's needs in considering his/her age, race, weight and gender could achieve more drug efficacy and less toxicity and side effects. 3D printers are of different types according to the working methods and initial materials. The most suitable techniques for 3D printing of medicines are nozzle-based deposition, printing-based inkjet systems and stereolithography. It is necessary to consider several parameters such as drug stability and drug loading capacity in a 3D printing technology to acquire an optimal drug release profile. This review introduces 3D printing technique and the related hardware commonly used. This article also summarizes the variety of dosage forms obtained using this technology.

کلیدواژه‌ها [English]

  • 3D printing technique
  • additive manufacturing
  • rapid prototyping
  • novel drug delivery systems
  • drug release profile

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