بررسی خواص ضدمیکروبی و ترمیمی نانوالیاف کتیرا

نوع مقاله: تالیفی

نویسندگان

1 دانشجوی کارشناسی ارشد

2 عضو هیات علمی دانشگاه تربیت مدرس

چکیده

پلیمرها به تازگی بیشترین کاربرد را در انواع صنایع، به‌ویژه در صنایع پزشکی ایفا کرده‌اند. پلیمرهای طبیعی از جمله پلی‌ساکاریدها، با داشتن منشأ طبیعی از جمله باکتریایی، گیاهی و حیوانی قابلیت شبیه‌سازی ساختار زیستی بدن را دارند. بنابراین، می‌توانند کاربرد زیادی در مهندسی بافت و ساخت داربست‌های ترمیم بافت و سامانه‌های نوین ‌درمانی و دارورسانی ایفا کنند. افزون بر خواص خوب زیستی پلی‌ساکاریدها، قابلیت آن‌ها برای استفاده در سامانه‌های نانوساختار ازجمله نانوفیلم‌ها، نانوالیاف و نانوذرات اثبات شده است. کتیرا پلیمری طبیعی، کربوهیدراتی پیچیده، ناهمگن و آنیونی و متشکل از پلی‌ساکاریدهاست و به‌خاطر ویژگی‌های عالی فیزیکی، شیمیایی و زیستی از جمله ساختار، رفتار گرمایی، زیست‌تخریب‌پذیری، زیست‌سازگاری و فعالیت ضدمیکروبی در درمان و ترمیم زخم‌های ناشی از سوختگی و عفونت استفاده می‌شود. در سال‌های اخیر از کتیرا به‌عنوان هیدروژل ابرجاذب، نانوکپسول ضدمیکروب و از موسیلاژ کتیرا برای درمان زخم سوختگی ضخیم به‌صورت موضعی استفاده شده است. از نانوالیاف کتیرا نیز به عنوان زخم‌پوش، داربست و سامانه رهایش دارو استفاده شده است. در این مقاله مروری، خواص و کاربرد کتیرا در زمینه ترمیم بافت و دارورسانی و همچنین سامانه‌های نانوالیاف کتیرا در ترکیب با سایر پلیمرها بررسی می‌شود. همچنین، بر خواص ضدمیکروبی و ترمیم‌ بافت کتیرا تأکید بیشتری می‌شود.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Antibacterial and Reconstructive Applications of Gum Tragacanth Nanofibers

نویسندگان [English]

  • Rashid Meghdadi Kasani 1
  • Soheil Boddohi 2
چکیده [English]

Recently, polymers have shown great potential in biological science. Natural polymers including polysaccharides with bacterial, animal and fungal sources are a good candidate to mimic structure of biological materials such as extracellular matrices. Therefore, they have gained much attentionin therapeutic and tissue engineering applications. Polysaccharides among all natural polymers show promising potential for preparation of nanostructured carriers. Nowadays, nanofilms, nanoparticles, and nanofibers are well known carriers for drug delivery and tissue engineering applications. Gum tragacanth is a natural polymer and a complex carbohydrate including polysaccharide structure. It comprises excellent physical, chemical and biological properties such as thermal and mechanical behavior; biodegradability, biocompatibility, and antimicrobial effect on wound healing and burn infections. Previously, raw gum tragacanth used to be applied locally as a superabsorbent hydrogels, antibacterial nanocapsuls, and mucilage for would healing treatment and deep wound scar. In recent years nanofibers have shown potential in tissue scaffold and mats for delivery of therapeutic drugs. Researchers have developed methods to engineer nanostructured fibers and tuned physical parameters such as diameter, tensile modulus, and degradation properties. In this review some of the recent works on gum tragacanth nanofibers and incorporation with other polymeric materials are discussed. Antimicrobial and would healing characteristics of gum tragacanth is being highlighted.

کلیدواژه‌ها [English]

  • gum tragacanth
  • nanofiber
  • tissue engineering
  • drug delivery
  • antimicrobial
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