Applications of Polymeric Reagents in Chemical Library Generation

Considering the ever increasing activities in research laboratories of pharmaceutical and agricultural industries to synthesize new compounds, the necessity of designing new processes with greater time efficiency, which may lead to more structural variation seems highly plausible. As part of the dramatic changes associated with the need for preparing compound libraries in pharmaceutical and agrochemical research laboratories, industries search for new technologies allow for the automation of synthetic processes. In practical terms, in addition to designing new equipment, the synthesis must also be designed so that the reactions can be carried out with the equipment. In this context, using polymeric reagents is quite useful. Extraction and chromatographic purification can be avoided by using these reagents, and so robots can carry out all the manipulations required. This review is aimed to highlight some of the most important applications of these promising materials in chemical library generation and synthesis of natural products.