A review of the application of polyacrylamide nanocomposites in wound dressings

Document Type : compile

Authors

1 Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

2 --

3 ..

10.22063/basparesh.2025.35697.1740

Abstract

Chronic infected wounds remain a significant challenge in tissue regeneration and clinical wound management. Smart hydrogel-based wound dressings, particularly those utilizing polyacrylamide (PAM), have gained increasing attention due to their three-dimensional structure, high water absorption capacity, biocompatibility, and drug-loading potential. These hydrogels create an optimal environment for wound healing, providing moisture retention and facilitating nutrient and oxygen exchange. However, limitations such as poor mechanical strength, instability under stress, and lack of intrinsic antibacterial properties have restricted their broader application. In recent years, the incorporation of functional nanoparticles—such as silver nanoparticles (AgNPs), Cellulose Nanocrystals (CNC), and photodynamic nanoparticles (Ce6/CMCS)—has significantly enhanced the mechanical, biological, and antibacterial properties of PAM-based hydrogels. The nanoparticles contribute to improving the structural integrity, enhancing the strength, and enabling controlled release of therapeutic agents, which accelerates the healing process. This review systematically explores the impact of various nanoparticles on the structural, mechanical, and functional performance of PAM hydrogels. Key mechanisms including controlled drug release, stimuli-responsive behavior, and enhanced wound healing are critically discussed. The findings suggest that PAM nanocomposites play a pivotal role in the development of next-generation wound dressings, opening new avenues for intelligent, targeted tissue regeneration therapies with the potential for personalized medical applications.

Keywords

Main Subjects

Basparesh

Articles in Press, Accepted Manuscript
Available Online from 20 July 2026

Files

Share

How to cite

Statistics