Application of Polyacrylamide Nanocomposites in Wound Dressings

Document Type : compile

Authors

1 Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

2 --

3 ..

10.22063/basparesh.2025.35697.1740

Abstract

Chronic infected wounds remain a major challenge in tissue regeneration and clinical wound management. Smart hydrogel-based wound dressings, particularly those using polyacrylamide (PAM), have gained increasing attention due to their three-dimensional structure, high water absorption capacity, biocompatibility, and drug-loading potential. These hydrogels provide an optimal environment for wound healing by moisture retention and facilitating nutrient and oxygen exchange. However, limitations such as poor mechanical strength, instability under stress, and lack of intrinsic antibacterial properties have limited their widespread application. In recent years, the incorporation of functionalized nanoparticles, such as silver nanoparticles (AgNPs), cellulose nanocrystals (CNC), and photodynamic nanoparticles nanoparticles (chloro-e6-carboxymethyl chitosan, Ce6/CMCS), has significantly enhanced the mechanical, biological, and antibacterial properties of PAM-based hydrogels. The nanoparticles contribute to improve structural integrity, increase strength, and enable controlled release of therapeutic agents, which accelerates wound healing process. This study systematically reviews the impact of various nanoparticles on the structural, mechanical, and functional performance of PAM hydrogels. Also, key mechanisms including controlled drug release, stimuli-responsive behavior, and enhanced wound healing are critically discussed. The findings suggest that PAM nanocomposites play an important role in the development of next-generation wound dressings and open new avenues for intelligent and targeted tissue regeneration therapies that have the potential for personalized medical applications.

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