Application of Polyacrylamide Nanocomposites in Wound Dressings

Document Type : compile

Authors

1 Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

2 --

3 ..

10.22063/basparesh.2025.35697.1740

Abstract

Chronic infected wounds remain a major challenge in tissue regeneration and clinical wound management. Smart hydrogel-based wound dressings, particularly those using polyacrylamide (PAM), have gained increasing attention due to their three-dimensional structure, high water absorption capacity, biocompatibility, and drug-loading potential. These hydrogels provide an optimal environment for wound healing by moisture retention and facilitating nutrient and oxygen exchange. However, limitations such as poor mechanical strength, instability under stress, and lack of intrinsic antibacterial properties have limited their widespread application. In recent years, the incorporation of functionalized nanoparticles, such as silver nanoparticles (AgNPs), cellulose nanocrystals (CNC), and photodynamic nanoparticles nanoparticles (chloro-e6-carboxymethyl chitosan, Ce6/CMCS), has significantly enhanced the mechanical, biological, and antibacterial properties of PAM-based hydrogels. The nanoparticles contribute to improve structural integrity, increase strength, and enable controlled release of therapeutic agents, which accelerates wound healing process. This study systematically reviews the impact of various nanoparticles on the structural, mechanical, and functional performance of PAM hydrogels. Also, key mechanisms including controlled drug release, stimuli-responsive behavior, and enhanced wound healing are critically discussed. The findings suggest that PAM nanocomposites play an important role in the development of next-generation wound dressings and open new avenues for intelligent and targeted tissue regeneration therapies that have the potential for personalized medical applications.

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Main Subjects

References

  1. Kamoun E.A., Kenawy E.R.S., and Chen X., A Review on Polymeric Hydrogel Membranes for Wound Dressing Applications: PVA-Based Hydrogel Dressings, J. Adv. Res., 8, 217-233, 2017.
  2. Li Y., Huang G., Zhang X. et al., Magnetic Hydrogels and Their Potential Biomedical Applications, Adv. Funct. Mater., 23, 660-672, 2013.
  3. Percival S.L., McCarty S.M., and Lipsky B., Biofilms and Wounds: An Overview of the Evidence, Adv. Wound Care, 4, 373-381, 2015.
  4. Gore M., Jadhav S., Schultz G., and Mehta D., Evaluation of Safety and Efficacy of Barrier Foam Dressing in Patients with Exuding Wounds, Biomed. J. Sci. Tech. Res., 33, 26292-26297, 2021.
  5. Hu Y., Yu L., Dai Q., Hu X., and Shen Y., Multifunctional Antibacterial Hydrogels for Chronic Wound Management, Biomater. Sci., 12, 2460-2479, 2024.
  6. Aswathy S.H., Narendrakumar U., and Manjubala I., Commercial Hydrogels for Biomedical Applications, Heliyon, 6, e03719, 2020.
  7. Fathinejad H. and Karimi E., Synthesis and Characterization of Polyacrylamide-Based Antibacterial Hydrogel Nanocomposite, Soft Mater., 22, 295-302, 2024.
  8. Sabbagh F. and Muhamad I.I., Physical and Chemical Characterisation of Acrylamide-Based Hydrogels, Aam, Aam/NaCMC and Aam/NaCMC/MgO, J. Inorg. Organomet. Polym. Mater., 27, 1439-1449, 2017.
  9. Rajendran N.K., Kumar S.S.D., Houreld N.N., and Abrahamse H., A Review on Nanoparticle Based Treatment for Wound Healing, J. Drug Deliv. Sci. Technol., 44, 421-430, 2018.
  10. Ferfera-Harrar H., Berdous D., and Benhalima T., Hydrogel Nanocomposites Based on Chitosan-g-Polyacrylamide and Silver Nanoparticles Synthesized Using Curcuma longa for Antibacterial Applications, Polym. Bull., 75, 2819-2846, 2018.
  11. Ferrag C., Li S., Jeon K. et al., Polyacrylamide Hydrogels Doped with Different Shapes of Silver Nanoparticles: Antibacterial and Mechanical Properties, Colloids Surf. B Biointerfaces, 197, 111397, 2021.
  12. Awasthi S., Gaur J.K., Bobji M.S., and Srivastava C., Nanoparticle-Reinforced Polyacrylamide Hydrogel Composites for Clinical Applications: A Review, J. Mater. Sci., 57, 8041-8063, 2022.‏
  13. Kang T., Guo Z., Lu Y. et al., Hybrid Hydrogels of Polyacrylamide and Self‑Assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing, Biomacromolecules, 25, 7475‑7484, 2024.
  14. Bardajee G.R., Dianatnejad N., Mahmoodi N.O., and Mahmoodain H., Mechanical Properties and Development of Silver Nanoparticle-Enhanced Alginate-Polyacrylamide Double Network Hydrogel, J. Polym. Res., 31, 343, 2024.
  15. Singh S.K., Dhyani A., and Juyal D., Hydrogel: Preparation, Characterization and Applications, Pharma Innov., 6, 25, 2017.
  16. Ahmed E.M., Hydrogel: Preparation, Characterization, and Applications: A Review, J. Adv. Res., 6, 105-121, 2015.
  17. Park K., Chen J., and Park H., U.S. Patent No. 6,271,278, 2001.
  18. Omidian H., Qiu Y., Yang S. et al., U.S. Patent No. 6,960,617, 2005.
  19. Omidian H., Rocca J.G. and Park K., Elastic, Superporous Hydrogel Hybrids of Polyacrylamide and Sodium Alginate, Macromol. Biosci., 6, 703-710, 2006.
  20. Juby K.A., Dwivedi C., Kumar M. et al., Silver Nanoparticle-Loaded PVA/Gum Acacia Hydrogel: Synthesis, Characterization and Antibacterial Study, Carbohydr. Polym., 89, 906-913, 2012.
  21. Boonkaew B., Suwanpreuksa P., Cuttle L. et al., Hydrogels Containing Silver Nanoparticles for Burn Wounds Show Antimicrobial Activity without Cytotoxicity, J. Appl. Polym. Sci., 131, 40215, 2014.
  22. Hoellman D.B., Pankuch G.A. and Appelbaum P.C., Antistaphylococcal Activity of CB-181963 (CAB-175), Antimicrob. Agents Chemother., 48, 4037-4039, 2004.
  23. Kanatt S.R. et al., Active Chitosan–Polyvinyl Alcohol Films with Natural Extracts, Food Hydrocoll., 29, 290-297, 2012.
  24. Abd El-Mohdy H.L., Radiation Synthesis of Nanosilver/Poly Vinyl Alcohol/Cellulose Acetate/Gelatin Hydrogels for Wound Dressing, J. Polym. Res., 20, 177, 2013.
  25. Baker C. et al., Synthesis and Antibacterial Properties of Silver Nanoparticles, J. Nanosci. Nanotechnol., 5, 244-249, 2005.
  26. Zhang L. et al., AIE Multinuclear Ir (III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance, Adv. Sci., 6, 1802050, 2019.
  27. Zhang L., Tang Y.J., Zhang W.Q. et al., Polyhydroxy Structure Orchestrates the Intrinsic Antibacterial Property of Acrylamide Hydrogel as a Versatile Wound-Healing Dressing, Front. Bioeng. Biotechnol., 12, 1396892, 2024.
  28. Indrakumar S., Dash T.K., Mishra V. et al., Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review, ACS Polym. Au, 4, 168-188, 2024.
  29. Rumon M.M.H., Sarkar S.D., Uddin M.M. et al., Graphene Oxide Based Crosslinker for Simultaneous Enhancement of Mechanical Toughness and Self-Healing Capability of Conventional Hydrogels, RSC Adv., 12, 7453-7463, 2022.
  30. Pino P., Bosco F., Mollea C., and Onida B., Antimicrobial Nano-Zinc Oxide Biocomposites for Wound Healing Applications: A Review, Pharmaceutics, 15, 970.

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