A Review on Biomedical Applications of Chitosan

Document Type : other

Authors

1 Department of Chemistry, College of Science, Shahid Beheshti University, Tehran, Iran

2 Shiraz university

3 Shahid Beheshti university

10.22063/basparesh.2025.3703.1709

Abstract

Chitosan is a multifunctional biopolymer derived from chitin. It has attracted significant attention in the biomedical field due to its outstanding properties and diverse applications. This review provides a comprehensive analysis of the versatile biomedical applications of chitosan, including drug delivery, tissue engineering, wound healing, and regenerative medicine. The unique characteristics of chitosan, including biocompatibility, biodegradability, antimicrobial activity, and bioadhesive properties, make it an ideal candidate for various biomedical applications. In drug delivery systems, chitosan serves as a promising carrier for controlled and targeted drug release, improving therapeutic efficacy, and reducing adverse effects. Its biocompatible nature and nontoxicity make it suitable for encapsulating a wide range of therapeutics for systemic or localized delivery. In addition, the role of chitosan in tissue engineering and regenerative medicine is very important.
Chitosan scaffolds provide a conducive environment for cell growth, differentiation, and tissue regeneration, enabling the development of artificial organs, implants, and engineered tissues. The bioadhesive properties of chitosan facilitate cell adhesion and promote tissue repair and regeneration in wound healing applications. The present review also addresses the growing importance of chitosan in hemostatic technologies, where its ability to induce hemostasis and prevent infection improve wound care management. Furthermore, chitosan-based nanoparticles and scaffolds have revolutionized biomedical research by enabling convenient approaches for drug delivery, gene therapy, and tissue regeneration. Consequently, this review emphasizes the essential role of chitosan in advancing biomedical technologies and revolutionizing therapeutic interventions. The multifunctional properties of chitosan, coupled with ongoing research and innovations in this field, hold promise for the development of novel biomedical solutions with broad implications for healthcare practices and improved patient outcomes.   

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References

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