hybrid biodegradable scaffolds in tissue engineering and wound dressing -A review

Document Type : translation

Authors

1 Department of wood and paper Technical and Vocational University (TVU), Tehran, Iran

2 2. Surgeon and Obstetrician, Isfahan University of Medical Sciences

3 tehran university

Abstract

Degradable polymers have countless applications in the field of biomedicine, especially in the field of tissue engineering and drug delivery, degradable polymers have a special place in drug delivery and especially nanomedicine, one of its most important features is non-toxicity, degradability, ability Drug carrying, the ability to deliver drugs and especially in the production of wound dressings are widely used. In this review article, the effect of biodegradable scaffolds formed with antibacterial, drug delivery, waterproof properties on wounds and tissue repair is studied. was placed, the results showed that the scaffolds made of biodegradable substrate have suitable resistances in order to provide tissue repair and prevent the creation and spread of effective bacteria and microbes in the wound. Degradable and its applications have been studied in connection with various drugs and restorative materials, and chitosan, alginate, cellulose, nanocellulose, polycaprolactone, polylactic acid, gelatin, polyvinyl alcohol, collagen, polyhydroxyalkavanate are the most used components. have been for the production of biodegradable scaffolds, the comparisons showed that chitosan, as a very suitable substrate for drug delivery, had an effective antibacterial function in the production of waterproof wound dressings. It is worth mentioning that PVA, PCL, PLA were the most important biodegradable polymers used in wound healing scaffolds.

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