Hybrid Biodegradable Scaffolds in Tissue Engineering and Wound Dressings- A Review

Document Type : translation

Authors

1 Department of wood and paper Technical and Vocational University (TVU), Tehran, Iran

2 2. Surgeon and Obstetrician, Isfahan University of Medical Sciences

3 tehran university

Abstract

Biodegradable polymers have many applications in the field of biomedicine, especially in the field of tissue engineering and drug delivery systems. One of their most important features is non-toxicity, degradability, ability to carry and deliver drug, and widespread use in the production of wound dressings. In this article, the effect of some biodegradable scaffolds formed with antibacterial, biodegradability, biocompatibility, drug delivery, and waterproof properties on wound healing and tissue repair has been reviewed. Biodegradable scaffolds have the ability to restore tissue and prevent the spread of bacteria at the wound site. In the present study, various types of scaffolds with biodegradable nanofibers have been
compared and their applications have been investigated in connection with various drugs and restorative materials. Chitosan, alginate, nanocellulose, polycaprolactone (PCL), polylactic acid (PLA), gelatin, polyvinyl alcohol (PVA), collagen, polyhydroxyalkanoate are among the most useful polymers for producing biodegradable scaffolds. The comparison showed that chitosan, as a very suitable substrate for drug delivery, has an effective antibacterial function in making waterproof wound dressings. It should be mentioned that PVA, PCL, PLA are the most important biodegradable polymers used in wound healing scaffolds.

Keywords

Main Subjects

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