A Review on Various Methods for Preparation of Self-healing Hydrogels based on Gelatin for Biological Applications

Document Type : compile

Authors

1 Department of chemistry, Institute for Advanced Studies in Basic Sciences (IASBS)

2 Academic Staff, Institute for Advanced Studies in Basic Sciences (IASBS)

Abstract

Hydrogels are insoluble and three-dimensional polymer networks that have high water absorption and are used as an extracellular matrix for biomedical applications due to their appropriate elasticity and network structure. Self-healing is a property that enables the material to heal damages spontaneously and automatically and return to its normal state. This feature increases the useful life of materials and preserves their main functional properties. Different types of natural, synthetic, and semi-synthetic polymers can be used to prepare self-healing hydrogels. Gelatin is a natural polymer with a protein structure, hydrophilic, biocompatible and biodegradable, and consists of a sequence of eighteen types of amino acids such as glycine, proline, hydroxyproline, alanine, etc., which are connected by peptide bonds. Gelatin is obtained from hydrolyzing collagen that makes up most of the proteins in skin, bone, and cartilage. Due to its suitable biocompatibility, biodegradability, lack of immune response, the ability to modify and prepare numerous derivatives, and its commercial availability, gelatin has been able to be very efficient in preparing a variety of self-healing hydrogels with various applications. In this article, the preparation and application of different types of gelatin-based self-healing hydrogels in various biological fields such as the preparation of tissue engineering scaffolds, drug delivery, motion sensors, wound dressings for the repair of infectious and diabetic wounds, 3D printing for the preparation of scaffolds, sustained protein release, and adhesives used in laparoscopic surgeries have been reviewed.

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References

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