A review of the application of chitosan in tissue engineering

Document Type : other

Authors

1 Department of Chemistry, College of Science, Shahid Beheshti University, Tehran, Iran

2 Department of Chemistry, Kashan University

3 Department of Chemistry, College of Science, Shiraz University

Abstract

In recent years, there have been rapid advances in the use of bioactive materials in tissue

engineering applications. Therefore, there has been an increasing demand to prepare materials with

suitable physical, biological, and mechanical properties as well as predictable degradation

behavior. Materials based on chitosan, which is derived from chitin, is a unique biopolymer, that

shows outstanding properties due to its exceptional properties such as antibacterial, plasticity in

different structures, and the ability to make with A wide range of bioactive substances, a non-toxic

polysaccharide, in addition to biocompatibility and biodegradability, are ideal bioactive

substances. The properties of chitosan, such as its poor solubility in water or organic solvents, can

limit its use for a specific application. An excellent way to improve or create new properties of

chitosan is to chemically modify the chain, generally by linking functional groups, without

changing the primary skeleton in order to preserve the original properties. Chitosan is a natural

polymer from renewable resources obtained from crustaceans such as shrimp. Due to its natural

abundance and cost-effectiveness, it has attracted the attention of many researchers due to its use

as an alternative to scaffold construction in tissue engineering. The purpose of this review is to

provide an overview of chitosan and chitosan derivatives used for tissue engineering.

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Basparesh

Articles in Press, Accepted Manuscript
Available Online from 09 January 2024

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