A Review of the Application of Chitosan in Tissue Engineering

Document Type : other

Authors

1 Department of Chemistry, College of Science, Shahid Beheshti University, Tehran, Iran

2 Department of Chemistry, Kashan University

3 Department of Chemistry, College of Science, Shiraz University

Abstract

In recent years, there have been rapid advances in the use of bioactive materials in tissue engineering applications. Therefore, there is an increasing demand for materials with suitable physical, biological and mechanical properties as well as predictable degradation behavior. These materials show outstanding properties such as being antibacterial, malleable in different structures and can be made with a wide range of bioactive materials. For this reason, materials based on chitosan polysaccharide are non-toxic and in addition to biocompatibility and biodegradability, they are also ideal bioactive material. The properties of chitosan, such as poor solubility in water or organic solvents, can limit its use for a
specific application. An excellent way to improve or create new properties of chitosan is chemical chain modification generally by linking functional groups, without changing the primary skeleton in order to preserve the original properties. Chitosan is a natural polymer from renewable resources that is obtained from crustaceans such as shrimp. The natural abundance and cost-effectiveness of chitosan has attracted the attention of many researchers due to its use as an alternative for making scaffolds in tissue engineering. The purpose of this article is to provide an overview of chitosan and chitosan derivatives that are used in tissue engineering.

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References

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