Solid dispersion technique to enhance the solubility of poorly water-soluble drugs

Document Type : compile

Authors

1 -

2 Iran polymer and petrochemical institute

Abstract

Abstract

The solubility and permeability of drugs are the most important biopharmaceutical properties that effect their bioavailability. In the Biopharmaceutics Classification System (BCS), there are a large number of active pharmaceutical ingredients (APIs) with low solubility (BCS classes II and IV) that are only a minority on the market. Therefore, it is necessary to offer a solution for increasing thier solubility. There are many preparation methods to enhance the solubility and dissolution rate of drugs and thereby absorption in the gastrointestinal tract. Among them, solid dispersion method is considered one of the most important methods. Since 1960s, the development of pharmaceutical formulations based on the solid dispersion method has undergone great progress. Solvent-based and melting methods can be mentioned for the preparation of drug-containing systems. The use of different carriers from a single polymeric carrier to multiple carriers containing emulsifier in the design of solid dispersion formulations has led to the improvement of the stability and performance of these systems. In this article, the solid dispersion technique for the preparation of pharmaceutical formulations is introduced, and also a summary of the preparation methods and the recent advances in this field will be reviewed.

Keywords

Main Subjects

Basparesh

Articles in Press, Accepted Manuscript
Available Online from 18 July 2023

Files

Share

How to cite

Statistics