A Review on Covalent Organic Frameworks and their Application in Drug Delivery

Document Type : compile

Authors

1 Iran, Tehran, Iran University of Science and Technology, Department of new Technologies

2 Assistant Professor of Nanobiomaterials Engineering, School of New Technologies, Iran University of Science and Technology (IUST), Tehran, Iran

Abstract

Today, cancer is the second leading cause of death worldwide. Covalent Organic Frameworks (COFs) are new emerging 2 or 3D porous nanomaterials that have attracted tremendous attention. These materials are composed of light elements including carbon, boron, hydrogen, which are connected with strong covalent bonds. Due to their low density, high surface area, and intrinsic porosity, suitable crystallinity, and high thermal stability, these materials have become a suitable candidate for many applications such as sensors, drug delivery, separation, catalysts, and adsorption. Due to their porosity and high loading capacity, COFs has the ability to encapsulate various types of therapeutic agents. These materials can modify with different functional groups to achieve targeted drug delivery and increase biocompatibility. Also, their metal-free nature has caused COFs to have a good perspective in drug delivery applications and have shown low cytotoxicity in in-vitro studies. In this review, different types of COFs and a number of studies conducted on these nanomaterials for drug delivery applications have been reviewed. In the last part, the upcoming challenges in this area have been discussed.

Keywords

Main Subjects

References

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