A Review on 4D printing technology in tissue engineering

Document Type : compile

Authors

Department of New Technologies/IUST

Abstract

3Dprinting” or additive manufacturing (AM) attempts to building constructs by using computer controlled layer-by-layer manner. 3D printing plays a pivotal role in the fabrication of systems utilized in the biomedical field, such as the creation of complex tissue constructs and scaffolds, customized drug delivery systems (DDS), and soft robots, among others. 4D printing is an extension of the concept of 3D printing by adding “time” as a fourth dimension. In other words, this technology is useful for creating constructs capable of changeable shape and functionality over time after triggered by stimuli such as temperature, moisture, electrical and magnetic fields, light and pH. 4D printing has shown interesting promise in biotechnology with a great shape control after printing by using stimuli responsive materials. For example, in tissue engineering the repairing process of tissue was known as a dynamic process and 3D printed structures are ineffective in this situation, while 4D printed structures can respond to the mentioned dynamic environment. In this study, a comprehensive review will be conducted on the utilization of stimuli-responsive materials in 4D-printed structures and their intriguing applications in tissue engineering.

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