Post-Modification of Electrospun Nanofibers with Bioactive Species through Click Reactions

Document Type : compile

Authors

1 PhD candidate/ University of Isfahan

2 Student - University of Isfahan -Department of Chemistry - Polymer Chemistry

3 Faculty/ University of Isfahan

Abstract

The regeneration process is not only affected by interactions between cells but also the surfaces chemistry of biomaterials. For this reason, modifying the surface of electrospun fibers with biomolecules is a suitable method to increase adhesion and cellular organization. There are two general approaches to modify electrospun nanofibers, which are performed in different ways. Loading biological agents in a polymer solution is a common method for trapping biomolecules in the scaffold structure, in which the molecule is located in the fibrous labyrinth and plays its role. However, due to the limitations of this method, post-modification methods have been considered as an alternative path. This type of modification can be achieved by physical adsorption of biomolecules on the fiber surface or by chemical bonding. Due to the capabilities of click chemistry, clickable electrospun structures provide a promising path for linking different biomolecules, that are suitable for different purposes of tissue engineering. In this article, the latest research performed on the functionalization and modification of electrospun structures with different types of click reactions are reviewed. Obviously, achieving smart systems that stimulate and control the cellular activities requires familiarity with the latest research in this field, which is the main goal of this review article.

Keywords

References

1.  Politi S., Carotenuto F., Rinaldi A., Di Nardo P., Manzari V., Albertini M.C. et al., Smart ECM-Based Electrospun Bioma-
terials for Skeletal Muscle Regeneration, Nanomaterials, 10, 1781-1800, 2020.
2.  Klein K.L., Melechko A.V., McKnight T.E., Retterer S.T., Rack P.D., Fowlkes J.D. et al., Surface Characterization and 
Functionalization of Carbon Nanofibers, J. Appl. Phys., 103, 3-30, 2008.
3.  Binder W.H. and Sachsenhofer R., ‘Click’ Chemistry in Polymer   and Material Science: An Update, Macromol. Rapid Commun.,  29, 952-981, 2008.
4.  Zou Y., Zhang L., Yang L., Zhu F., Ding M., Lin F. et al., “Click” Chemistry in Polymeric Scaffolds: Bioactive Materi-
als for Tissue Engineering, J. Control Release, 273, 160-179, 2018.
5.  Yet L., Five-Membered Ring Systems: With More than One N Atom, Prog. Heterocycl. Chem., 21, 224-260, 2009.
6. Geng Z., Shin J.J., Xi Y., Hawker C. J., Click Chemistry Strate-gies for the Accelerated Synthesis of Functional Macromol-
ecules, J. Polym. Sci., 11, 963-1042, 2021.
7.  Mbua N.E., Guo J., Wolfert M.A., Steet R., and Boons G.J., Strain-Promoted Alkyne–Azide Cycloadditions (SPAAC) 
Reveal new Features of Glycoconjugate Biosynthesis, Chem. Bio. Chem., 12, 1912-1921, 2011.
8.  Huang C.J. and Chang F.C., Using Click Chemistry to Fab-ricate Ultrathin Thermoresponsive Microcapsules through 
Direct Covalent Layer-by-layer Assembly, Macromolecules, 42, 5155-5166, 2009. 
9.  Lancuški A., Fort S., and Bossard F., Electrospun Azido-PCL Nanofibers for Enhanced Surface Functionalization by Click 
Chemistry, ACS Appl. Mater. Interfaces, 4, 6499-6504, 2012.
10. Lancuški A., Bossard F., and Fort S., Carbohydrate-Decorated PCL Fibers for Specific Protein Adhesion,  Biomacromol-
ecules, 14, 1877-1884, 2013.
11. Chang Z., Fang Y., Zhang Q., and Chen D., “Click” Chemistry for Facile Immo
Basparesh
Volume 13, Issue 2 - Serial Number 47
September 2023
Pages 17-27

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