Electrospun Asymmetric Multilayer Membranes and Cell-Incorporated Constructs: Two Strategies to Accelerate Skin Wound Healing

Document Type : compile

Authors

1 1Polymer Chemistry Research Laboratory, Department of Chemistry, University of Isfahan, Iran

2 PhD candidate/ University of Isfahan

3 Faculty/ University of Isfahan

Abstract

Wound healing is a complex process, and in some cases, it is accompanied by persistent inflammation, cell dysfunction, and angiogenesis limitations, which leads to long-term medical care, high cost, and poor quality of treatment. The use of antibiotics, dressings, and skin alternatives are current methods of wound healing treatments. However, the existing wound dressings are not yet capable of fully restoring all the structural and functional characteristics of the skin. Therefore, the development of asymmetric membranes with the ability to mimic the structure and function of the human skin multilayers has been considered as more efficient structures in facilitating wound healing as well as skin tissue engineering. Wet or dry/wet phase inversion, supercritical carbon dioxide (scCO2) phase inversion, and electrospinning of polymer solutions are the common methods for the fabrication of multilayer structures. Among these, the electrospinning technique, due to its ease and versatility, the possibility of using different polymers, and the possibility of tailoring dressings in terms of specific structures of skin layers is promising. Another generation of emerging therapies is based on loading cells with the potential of wound healing acceleration. In the first part of this review, the last achievements obtained polymers used in asymmetric structures are discussed and then the electrospun structures containing special cells are reviewed.

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