Role of Polymers Used in Hormone Delivery of Contraceptive Systems for Prevention of Pregnancy

Document Type : compile

Authors

1 School of Nursing and Midwifery, Yasuj University of Medical Science (YUMS), Yasuj, Iran. Postal code: 7591741417

2 Biomaterials Departments, Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran. P. O. Box: 14975/112

Abstract

Pregnancy contraceptive devices such as sub-dermal implants, intrauterine devices
(IUD), vaginal tools and transdermal patches recognized as common methods used to
long-term protection of pregnancy. Non-biodegradability of subdermal implants and IUDs,
also copper burst release in copper based IUD systems and need to surgical help to remove
them from patient body and rapid water solubility of microneedles in transdermal patches
demonstrated as their main drawback for long-term contraception. In this study polymers
properties, especially biodegradable polymers used in contraceptive tools for long-term uses
were surveyed. Further of review on the sub-dermal implants, IUDs, vaginal tools including
vaginal rings and hydrogel and also trans-dermal patches based microneedles, the role of
polymers in structural and performance properties of these systems were investigated. The
rates of biodegradability and hormone release are the main factors affected the performance
of contraceptive tools. Therefore, applying of biodegradable polymers with natural and
biological origins and synthetic polymers such as polylactic-co-glycolic acid (PLGA), due
to their biocompatibility, needless to remove from patient body and the controlled release
of hormone has attracted the attention of researches. The results showed that the sustained
release rate of the hormone was strongly correlated with the structural properties of the
polymer.

Keywords

Main Subjects

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