Evaluation of Polymer-based Drug Delivery Systems in Preventing AIDS

Document Type : compile

Authors

iran, tehran, iran polymer and petrochemical institute

Abstract

Technological advances in the field of novel polymeric drug delivery systems have
been formulated with long-term releases. Such formulations are a great method for
chronic diseases, especially when the lack of compliance may be effective in responding to
treatment. New drug delivery systems have provided an opportunity to overcome many of
the challenges associated with the treatment of AIDS through anti-retroviral drugs (ARVs)
and thus improving patients with AIDS. In this paper, a comprehensive review of the
different polymeric systems for release of ARVs to achieve its sustained release kinetics
has been addressed. Potentialities of different systems and routes for administration of ARV
drugs, such as transdermal, buccal and rectal delivery have been studied. Physico-chemical
properties, in vitro and in vivo performance such as sustained release from tablets, ceramic
implants, polymer nanoparticles, nano reservoirs, liposomes, polymer mixture, emulsions,
microemulsions, nanopowders and etc are summarized. Increasing awareness about
polymeric systems that cause the long-term release of ARVs will facilitate the development
of this strategy to achieve potential benefits. This review shows the significant potential of
novel polymeric drug delivery systems and polymer inhibitors used to treat AIDS patients
effectively with future ARVs.

Keywords

Main Subjects

References

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Basparesh
Volume 9, Issue 2 - Serial Number 31
September 2019
Pages 38-47

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