Polymers Used in Mucoadhesive Drug Delivery Systems

Document Type : compile

Author

Biomedical Engineering Group, Chemical Engineering Faculty, Tarbiat Modares University, Tehran, Iran

Abstract

Mucoadhesive polymers were first used in the early 1980s to design mucoadhesive
buccal drug delivery systems. These systems have been introduced as novel drug
delivery systems due to the ability to stick and stay on mucus membranes and slow release of
the drug and as suitable alternative to overcome the problems of common oral drug delivery
systems. Mucoadhesive systems can be prepared in various forms, such as tablet, gel, oral
film, spray, viscous solution and micro/nanoparticles, and can be used for drug delivery
from the buccal, sublingual, intestine, ocular, nasal, vaginal, and other mucosal routes.
Mucoadhesive polymers which are the most important component of the drug delivery
systems, are usually natural, synthetic or semi-natural hydrophilic macro-molecules,
containing functional groups forming hydrogen bonds, such as carboxyl and hydroxyl
groups, or amines. Hence, mucoadhesion depends on the reaction between the polymer and
the mucus and the adhesion strength is determined by the different polymer characteristics
and the medium conditions in which the polymer resides. In this article, the discussion
covers mucoadhesion mechanism and its effective factors; natural mucoadhesive polymers,
synthetic and semi-natural mucoadhesive polymers; the properties and characteristics of
these polymers; their application in the design and development of mucoadhesive systems
and also the new generation of mucoadhesive polymers such as thiolated mucoadhesive
polymers.

Keywords

Main Subjects

References

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Basparesh
Volume 9, Issue 2 - Serial Number 31
September 2019
Pages 3-14

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