Mucoadhesive Drug Delivery Systems

Document Type : compile

Author

Biomedical Engineering Group, Chemical Engineering Faculty, Tarbiat Modares University, Tehran, Iran

Abstract

Mucoadhesive systems are new drug delivery mechanisms that are considered highly
favorable in recent years due to the ability to stick and stay on the mucus and
release their drug content in a sustained manner. Drug delivery through the mucosa is a
good route for a large population of patients especially for those with swallowing problems.
This route has important advantages over the oral route, including bypassing hepatic
first pass metabolism and avoiding the drug degradation within the gastrointestinal tract.
Mucoadhesive dosage forms can be prepared in various forms, such as tablet, gel, oral film,
spray, viscous solution and micro/nanoparticle, and can be used in drug delivery through
the oral, intestine, ocular, nasal, vaginal, and other mucosal routes. The most important
component of these systems is the polymer. Mucoadhesive polymers, in addition to acting
as the mainstay of these formulations, also control the release and penetration of the drug,
thereby contributing to the therapeutic benefits of these systems. Hence, mucoadhesive
characteristics include factors related to bioadhesive polymers and the medium in which
the polymers reside. In this article, the mucoadhesive systems; various types of dosage
forms; mechanism and theories of mucoadhesion and factors affecting mucoadhesion are
discussed.

Keywords

Main Subjects

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