Application of 3D Printing Technology in Novel Drug Delivery Systems: A Review

Document Type : compile

Authors

1 Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran

2 2Department of life science engineering, Faculty of new sciences and technologies, University of Tehran, Tehran, Iran

Abstract

In 3D printing process, objects are made using a digital model data by adding a material, as layer by layer, to produce a desired geometry. In recent years, the application of 3D printing technology has been considered for the manufacture of pharmaceutical products with the ability of controlled drug delivery. The advantages of this approach include the ability to prepare personalized dosage forms for each patient with complex geometrical shapes along with simultaneous loading of several different drugs and excipients. Manufacturing of products containing low-solubility drugs, potent drugs and peptides as well as achieving the release of multi-drugs profiles are possible through 3D printing technique. The prepared dosage forms by 3D printing method based on patient's needs in considering his/her age, race, weight and gender could achieve more drug efficacy and less toxicity and side effects. 3D printers are of different types according to the working methods and initial materials. The most suitable techniques for 3D printing of medicines are nozzle-based deposition, printing-based inkjet systems and stereolithography. It is necessary to consider several parameters such as drug stability and drug loading capacity in a 3D printing technology to acquire an optimal drug release profile. This review introduces 3D printing technique and the related hardware commonly used. This article also summarizes the variety of dosage forms obtained using this technology.

Keywords

Main Subjects

References

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Basparesh
Volume 8, Issue 3 - Serial Number 28
December 2018
Pages 45-56

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