Cyclodextrin-based Polymeric Nanosponges with Capability of Loading/releasing Materials and Their Applications

Document Type : compile

Authors

1 MSc student at Iran polymer and petrochemical institute

2 academic staff of Iran polymer and petrochemical institute

3 Assistant Professor at the Iran polymer & petrochemical Institute

Abstract

Nanosponges are generally porous materials with nanometer-sized pores that are capable of loading molecules in their cavities. Physical-chemical properties of cyclodextrins in the late 19th century were fundamental. Cyclodextrins have been used as practical and economical advantages to improve the physico-chemical properties and medicinal properties such as increased solubility, stability and bioavailability of the drug molecules. Cyclodextrin-based nanosponges are porous and insoluble in aqueous solution which can be in crystalline or amorphous structure and spherical shape and can be formed by different types of cyclodextrins and their derivatives. Dimension and the polarity of porous polymers are affected by types of cyclodextrins, cross-linkers and degree of cross-linking. In addition, depending on the type of cross-linker, neutral or acidic polymeric nanosponges can be synthesized. These polymeric nanosponges have hydrophilic and hydrophobic parts that induce capability to entrap wide range of lipophilic or hydrophilic molecules by forming inclusion and non-inclusion complexes. These complexes are formed between molecules without making any coordination bond and the driving force to induce electrostatic, Van der Waals and hydrophobic interactions, release of conformational strains and charge-transfer interaction. Characterization of these types of polymeric nanosponges are performed by different methods like microscopy, solubility studies, zeta potential, DSC and FT-IR spectroscopy. Various factors such as type of polymer and guest, temperature and method of preparation can affect the formation and the performance of nanosponges. These nanosponges are used in a variety of fields such as pharmaceutical, textile, catalysts, cosmetics, agriculture and other areas.

Keywords

Main Subjects

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