Fabrication of Polyurethane-based Artificial Blood Vessel Implants

Document Type : compile

Authors

1 MSc student Iran polymer& petrochemical institute.

2 Assistant Professor at the Iran polymer & petrochemical Institute

3 Academic staff of Iran polymer& petrochemical institute.

Abstract

In patients suffering from peripheral arterial disease; where vessels narrow and/or lose their efficiency and kidney failure; where hemodialysis is performed through an arteriovenous (AV) fistula that connects an artery to a vein, to purify blood, three types of surgical treatment; namely angioplasty, endarterectomy, and bypass grafting are vigorously considered. In cases like acute artery stenosis and multi-focal stenosis, a bypass is generally used. In addition, burns can damage blood vessels and cause fluid loss. This may result in low blood volume (hypovolemia) and in this case a bypass graft surgery is inevitable. However, in some cases, patients lack appropriate vessels for autologous grafting (autologous grafting includes grafting of a tissue from one site to another site of the same body). Furthermore, in autologous transplantation, a patient undergoes two surgeries simultaneously. In this respect, researchers have focused on designing artificial blood vessels as vascular implants. A class of materials that is highly regarded promising is polyurethanes, due to a number of outstanding properties including blood compatibility, biocompatibility, and most importantly, capability to tailor desirable properties. This report focuses on application of polyurethanes as artificial blood vessels while the impact of key parameters such as design of the polyurethane backbone, surface modification, and bulk modification, on the polymer key properties including: toxicity, endothelialization, and platelets adhesion are reviewed

Keywords

Main Subjects

References

1.Kapadia M.R., Popowich D.A., and Kibbe M.R., Modified Prosthetic Vascular Conduits, Circulation, 117, 1873–1882, 2008.
2.Hess F., History of (MICRO) Vascular Surgery and the Developmentof Small-caliber Blood Vessel Prostheses (with Some Notes on Patency Rates and Re-endothelialization), Microsurgery,6, 59–69, 1985.
3.Grundfest-Broniatowski S., What Would Surgeons Like from Materials Scientists?, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.,5, 299–319, 2013.
4.Ravi S. and Chaikof E.L., Biomaterials for Vascular Tissue Engineering, Regener. Med., 5, 107–120, 2010.
5.Xue L. and Greisler H.P., Biomaterials in the Development and Future of Vascular Grafts, J. Vasc. Surg., 37, 472–480, 2003.
6.Ahmed M., Hamilton G., and Seifalian A.M., The Performanceof a Small-calibre Graft for Vascular Reconstructions in a Senescent Sheep Model, Biomaterials, 35, 9033–9040, 2014.
7.Franci G., Falanga A., Galdiero S., Palomba L., Rai M., MorelliG., and Galdiero M., Silver Nanoparticles as Potential Antibacterial Agents, Molecules, 20, 8856–8874, 2015.
8.Greene A.H., Bumgardner J.D., Yang Y., Moseley J., and HaggardW.O., Chitosan-coated Stainless Steel Screws for Fixationin Contaminated Fractures, Clin. Orthop. Related Res., 466, 1699–1704, 2008.
9.Goudie M.J, Brainard B.M., Schmiedt C.W., and Handa H., Characterization and In vivo Performance of Nitric Oxide-ReleasingExtracorporeal Circuits in a Feline Model of Thrombogenicity,J. Biomed. Mater. Res., 105, 539–546, 2017.
10.Jaganathan S.K., Supriyanto E., Murugesan S., Balaji A., and Asokan, M.K., Biomaterials in Cardiovascular Research: Applicationsand Clinical Implications, BioMed Res. Int., 2014, DOI: 10.1155/2014/459465.
11.Prisacariu C., Polyurethane Elastomers from Morphology to Mechanical Aspects, Springer-Verlag, New York, 5, 2011.
12.Boretos J.W and Pierce W.S., Segmented Polyurethane: A New Elastomer for Biomedical Applications, Science, 158, 1481-1482, 1967.
13.Aortec Polymers and Medical Devices, http://www.aortech.net, available in 2 May 2016.
14.Martin D.J., Warren L.A.P., Gunatillake P.A., Mccarthy S.J., Meijs G.F., and Schindhelm K., olydimethylsiloxane/Polyether-Mixed Macrodiol-Based Polyurethane Elastomers: Biostability,
Biomaterials, 21, 1021-1029, 2000.
15.Clarson J.M., Kuppurathanam S.S.V., Parker F.T., Todd R.S., Woven Fabric with Shape Memory Element Strands, US Pat. 8652284 B2, 2014.
16.Boland E.D., Matthews J.M., Pawlowski K.J., Simpson D.G., Wnek G.E., and Bowlin G.L., Electrospinning Collagen and Elastin: Preliminary Vascular Tissue Engineering, Front. Biosci.,9, 1422-1432, 2004.
17.Chuang T.W. and Masters K.S., Regulation of Polyurethane Hemocompatibility and Endothelialization by Tethered HyaluronicAcid Oligosaccharides, Biomaterials, 30, 5341–5351, 2009.
18.Liu Y., Inoue Y., Sakata S., Kakinoki S., Yamaoka T., and IshiharaK., Effects of Molecular Architecture of Phospholipid Polymers on Surface Modification of Segmented Polyurethanes,J. Biomater. Sci. Polym. Ed., 25, 474-486, 2014.
19.Liu Y., Inoue Y., Mahara A., and Kakinoki S., Durable Modificationof Segmented Polyurethane for Elastic Blood-contactingDevices by Graft-type 2- Methacryloyloxyethyl PhosphorylcholineCopolymer, Biomater. Sci., 25, 1514–1529, 2014.
20.Khan M., Yang J., Shi C., Lv J., Feng Y., and Zhang W., SurfaceTailoring for Selective Endothelialization and Platelet Inhibitionvia a Combination of SI-ATRP and Click Chemistry using Cys-Ala-Gly-Peptide, Acta Biomater., 20, 69–81, 2015.
21.Choi W.S., Joung Y.K., Lee Y., Bae J.W., Park H.K, Park Y.H., Park J.-Ch., and Park K.D., Enhanced Patency and Endothelializationof Small-caliber Vascular Grafts Fabricated by Coimmobilizationof Heparin and Cell-adhesive Peptides, ACS Appl. Mater., 8, 4336−4346, 2016.
22.Lukas K., Thomas U., Gessner A., Wehner D., Schmid T., Schmid C., and Lehle K., Plasma Functionalization of Polycarbonaturethaneto Improve Endothelialization-Effect of Shear Stress as a Critical Factor for Biocompatibility Control, J. Biomater. Appl., 30, 1417–1428, 2016.
23.Lehle K., Buttstaedt J., and Birnbaum D.E., Expression of AdhesionMolecules and Cytokines in Vitro by Endothelial Cells Seeded on Various Polymer Surfaces Coated with Titaniumcarboxonitride,J. Biomed. Mater. Res. Part A, 65, 393–401, 2003.
24.Kidane A.G., Burriesci G., Edirisinghe M., Ghanbari H., BonhoefferP., and Seifalian A.M., A Novel Nanocomposite Polymerfor Development of Synthetic Heart Valve Leaflets, Acta Biomater., 5, 2409–2417, 2009.
25.Zhou M., Wang W.-C., Liao Y.-G., Liu W.-Q., Yu M., and Ouyang C.-X., In vitro Biocompatibility Evaluation of Silk-fibroin/Polyurethane Membrane with Cultivation of HUVECs, Front. Mater. Sci., 8, 1–9, 2014.
26.Everett W., Scurr D.J., Rammou A., Darbyshire A., Hamilton G., and Mel A., A Material Conferring Hemocompatibility, Sci. Rep., 2016, DOI: 10.1038/srep26848.
27.Ruiz A., Rathnam K.R., and Masters K.S., Effect of HyaluronicAcid Incorporation Method on the Stability and Biological Properties of Polyurethane-hyaluronic Acid Biomaterials, J. Mater. Sci. Mater. Med., 25, 487–498, 2014.
Basparesh
Volume 7, Issue 3 - Serial Number 24
December 2017
Pages 63-72

Files

Share

How to cite

Statistics