Photopolymerization of Molecularly Imprinted Polymers and Their Photo-structure in Sensors

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Abstract

Today biosensors are synthesized in analytical chemistry, which are used for clinical diagnostics, environmental analysis, product monitoring, detection and drug screening.Synthetic biomimetic receptors like molecular imprinting polymer (MIPs) have shown to be a potential alternative to biomolecules as recognition element for biosensing. MIPs are capable of recognizing and binding target molecules with similar specificity and selectivity. One of the main challenges in MIP sensor development is the miniaturization of MIP structures and their interfacing with transducers or with microchips. So, photostructuring is suggested as one of the most suitable methods for patterning MIPs at the micro and nano scale on the transducer surface. In this study, photopolymerization, photopatterning of MIPs and their biosensing applications are described from 1972 up to 2012. Also, some lithoghraphy methods are recommended for MIP photostructures. MIP fifilms patterning by the use of optical methods is fairly compared to other structuring approaches such as soft lithography or mechanical microspotting, which is a new method with ability to synthesize nanostructure with high quality, precision and resolution. The contact and proximity printing, projection photolithography, microstereo-lithography, and near-fifield assisted optical lithography were all successfully combined with MIPs, resulting in specifificity and selectivity high-resolution patterns.

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References

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Volume 7, Issue 2 - Serial Number 23
October 2017
Pages 101-112

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