As a new and practical bio-engineering phenomenon, adding drag reducing polymers (DRPs) to blood has paramount effect on improving blood circulation in both in-vitro and in-vivo systems. It is proved that these agents could be employed for better resuscitation and revival of a disturbed blood flow and oxygen shortage in animal models. A minute concentration of DRPs was successfully applied in some animal models to improve blood flow and to increase tissue perfusion. Although there is not any report on human, yet the scientists vigorously extend their application to the living body. In the current study, apart from the introduction given on drag reduction effect and various drag reducing agents, some useful applications are presented on DRPs effect on blood circulation and the potential mechanisms to support them. The main studies which are carried out in vitro do reveal that by adding DRP, thickness of the cell free layer is reduced near the blood vessel wall.
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