Surface modification of magnetite nanoparticles via “Click” reaction and their used in biomedical applications

During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Magnetic nanoparticles (MNPs) have found various important applications in nanotechnology and nanomedicine in the areas of diagnosis, targeting and therapy. For all of these applications, MNPs surfaces must be tailored to improve biocompatibility properties and reduce aggregation. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among the chemical reactions which used for magnetic nanoparticles modification, Click chemistry with its unique features such as high aqueous competency, chemical orthogonality, and applicability toward diverse substrates has emerged as a burgeoning strategy for the development of surface-engineered polymers and nanoparticles with high selectivity and efficiency.