Dendrimers are a relatively new class of materials with unique molecular architectures and dimensions in comparison to linear polymers. Dendritic macromolecules containing several types of functional groups can be successfully synthesized through divergent or convergent method. The functional surface groups make them very hydrophilic and highly water soluble. Dendrimer diameters increase with generations in increments of up to 1 nm per generation, while molecular weight and number of functional surface groups increase exponentialy. An ideal dendritic drug-carrier must be non-toxic, non-immunogenic, and preferably biodegradable and present an adequate biodistribution. This review investigates recent advances in the application of drug-conjugated PAMAM dendrimers in drug delivery and finally, molecular dynamics simulations of PAMAM structures and their properties are discussed
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