Iran Polymer and Petrochemical Institute Basparesh 2252-0449 15 2 2025 08 23 A Review on Polymeric Microneedles and their Applications in Transdermal Drug Delivery A Review on Polymeric Microneedles and their Applications in Transdermal Drug Delivery 27 39 2159 10.22063/basparesh.2025.35542.1713 FA Fatemeh Babapour Biomedical Engineering Group, Chemical Engineering faculty, Tarbiat Modares University, Tehran Iran Fariba Ganji Tarbiat Modares University Journal Article 2024 09 14 Effective drug delivery with minimal invasion is one of the main advantages of microneedles, which have become very popular approach for transdermal drug delivery. Various types of minerals (silicone, ceramic, metal, etc.) and a large family of polymer materials are used to make microneedles. Compared to microneedles made from inorganic materials, polymeric microneedles offer several advantages, including biocompatibility, biodegradability, low toxicity, and reasonable price.  These microneedles can be divided into two categories: natural or synthetic based on the type of polymer used in their manufacture. Furthermore, microneedles can be categorized by their design, preparation method, and functionality into three types: integrated, two-segements, and core-shell microneedles. Each of these designs has different advantages, disadvantages, and applications in the medical field. Polymer microneedles can cause explosive or slow drug release in the body based on the solubility or degradation of the polymer after penetrating the skin and interacting with the body's interstitial fluid. In this article, while introducing the most common natural and synthetic polymers used in the manufacture of microneedles, the types of polymer microneedles manufactured in recent years and their practical results are reviewed. Effective drug delivery with minimal invasion is one of the main advantages of microneedles, which have become very popular approach for transdermal drug delivery. Various types of minerals (silicone, ceramic, metal, etc.) and a large family of polymer materials are used to make microneedles. Compared to microneedles made from inorganic materials, polymeric microneedles offer several advantages, including biocompatibility, biodegradability, low toxicity, and reasonable price.  These microneedles can be divided into two categories: natural or synthetic based on the type of polymer used in their manufacture. Furthermore, microneedles can be categorized by their design, preparation method, and functionality into three types: integrated, two-segements, and core-shell microneedles. Each of these designs has different advantages, disadvantages, and applications in the medical field. Polymer microneedles can cause explosive or slow drug release in the body based on the solubility or degradation of the polymer after penetrating the skin and interacting with the body's interstitial fluid. In this article, while introducing the most common natural and synthetic polymers used in the manufacture of microneedles, the types of polymer microneedles manufactured in recent years and their practical results are reviewed. http://basparesh.ippi.ac.ir/article_2159_fa18df804736b009d11f98f7f58cdc4a.pdf