Iran Polymer and Petrochemical Institute Basparesh 2252-0449 14 1 2024 05 21 A Review on Covalent Organic Frameworks and their Application in Drug Delivery A Review on Covalent Organic Frameworks and their Application in Drug Delivery 21 30 1975 10.22063/basparesh.2023.3340.1655 FA Samin Hosseinpour Iran, Tehran, Iran University of Science and Technology, Department of new Technologies Seyyed Mortaza Naghib Assistant Professor of Nanobiomaterials Engineering, School of New Technologies, Iran University of Science and Technology (IUST), Tehran, Iran Journal Article 2023 02 12 Today, cancer is the second leading cause of death worldwide. Covalent Organic Frameworks (COFs) are new emerging 2 or 3D porous nanomaterials that have attracted tremendous attention. These materials are composed of light elements including carbon, boron, hydrogen, which are connected with strong covalent bonds. Due to their low density, high surface area, and intrinsic porosity, suitable crystallinity, and high thermal stability, these materials have become a suitable candidate for many applications such as sensors, drug delivery, separation, catalysts, and adsorption. Due to their porosity and high loading capacity, COFs has the ability to encapsulate various types of therapeutic agents. These materials can modify with different functional groups to achieve targeted drug delivery and increase biocompatibility. Also, their metal-free nature has caused COFs to have a good perspective in drug delivery applications and have shown low cytotoxicity in in-vitro studies. In this review, different types of COFs and a number of studies conducted on these nanomaterials for drug delivery applications have been reviewed. In the last part, the upcoming challenges in this area have been discussed. Today, cancer is the second leading cause of death worldwide. Covalent Organic Frameworks (COFs) are new emerging 2 or 3D porous nanomaterials that have attracted tremendous attention. These materials are composed of light elements including carbon, boron, hydrogen, which are connected with strong covalent bonds. Due to their low density, high surface area, and intrinsic porosity, suitable crystallinity, and high thermal stability, these materials have become a suitable candidate for many applications such as sensors, drug delivery, separation, catalysts, and adsorption. Due to their porosity and high loading capacity, COFs has the ability to encapsulate various types of therapeutic agents. These materials can modify with different functional groups to achieve targeted drug delivery and increase biocompatibility. Also, their metal-free nature has caused COFs to have a good perspective in drug delivery applications and have shown low cytotoxicity in in-vitro studies. In this review, different types of COFs and a number of studies conducted on these nanomaterials for drug delivery applications have been reviewed. In the last part, the upcoming challenges in this area have been discussed. http://basparesh.ippi.ac.ir/article_1975_61d17176a8978c2887cd4f460587c92c.pdf