Iran Polymer and Petrochemical Institute Basparesh 2252-0449 14 1 2024 05 21 A Review on 4D Printing Technology in Tissue Engineering A Review on 4D Printing Technology in Tissue Engineering 12 20 1964 10.22063/basparesh.2023.3365.1660 FA Shadi Zarshad Department of New Technologies/IUST Mohammad Aghajani Hashjin Department of New Technologies/IUST Journal Article 2023 03 07 3D-printing or additive manufacturing (AM) attempts to building objects by using computer-controlled layer-by-layer manner. 3D printing plays a essential role in the fabrication of systems utilized in the biomedical field, such as the creation of complex tissue structures and scaffolds, customized drug delivery systems (DDS), and soft robots. 4D-printing is an extended concept of 3D-printing by adding time as a fourth dimension. In other words, this technology makes it possible to change the shape and function of the printed object over time after triggered by stimuli such as temperature, moisture, electrical and magnetic fields, light and pH. 4D printing has shown interesting promise in biotechnology with a great shape control after printing by using stimuli-responsive materials. For example, in tissue engineering the repairing process of tissue was known as a dynamic process and 3D printed structures are ineffective in this dynamic environment, while 4D printing technology, due to its unique features, makes it possible to use scaffolds printed by this method for planting in the intended environment. In this study, the use of stimuli-responsive materials in 4D-printed structures and their attractive applications in tissue engineering have been reviewed. 3D-printing or additive manufacturing (AM) attempts to building objects by using computer-controlled layer-by-layer manner. 3D printing plays a essential role in the fabrication of systems utilized in the biomedical field, such as the creation of complex tissue structures and scaffolds, customized drug delivery systems (DDS), and soft robots. 4D-printing is an extended concept of 3D-printing by adding time as a fourth dimension. In other words, this technology makes it possible to change the shape and function of the printed object over time after triggered by stimuli such as temperature, moisture, electrical and magnetic fields, light and pH. 4D printing has shown interesting promise in biotechnology with a great shape control after printing by using stimuli-responsive materials. For example, in tissue engineering the repairing process of tissue was known as a dynamic process and 3D printed structures are ineffective in this dynamic environment, while 4D printing technology, due to its unique features, makes it possible to use scaffolds printed by this method for planting in the intended environment. In this study, the use of stimuli-responsive materials in 4D-printed structures and their attractive applications in tissue engineering have been reviewed. http://basparesh.ippi.ac.ir/article_1964_502dfd3182d371d024fd95b040e5c473.pdf